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1.
What is HLA antigen?
.
The main function of this substance is to ensure that cells can recognize each other and induce an immune response, ultimately achieving the function of regulating the immune response
1.
What is HLA antigen?
What is HLA antigen? HLA antigen is the expression product of the human Major Histocompatibility Complex (MHC)
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The main function of this substance is to ensure that cells can recognize each other and induce an immune response, ultimately achieving the function of regulating the immune response
Moreover, the distribution of HLA is very extensive.
HLA-B27 molecular structure
HLA-B27 molecular structure2.
The relationship between HLA antigen and ankylosing spondylitis?
The relationship between HLA antigen and ankylosing spondylitis?
As early as 1973, related studies confirmed that the expression of HLA-B27 antigen has a high degree of disease correlation with ankylosing spondylitis (AS), and this correlation is the strongest and most known association between HLA and disease so far.
Typical
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Typical
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From ankylosing spondylitis to the appearance of the characteristic spinal changes and sacroiliitis changes seen in clinical X-rays, the best treatment opportunity has been lost, and the disability rate is high, but the early onset is hidden and the symptoms are diverse.
The symptoms of low back pain and morning stiffness are similar to many diseases and are easy to be misdiagnosed.
Therefore, the HLA-B27 test is very important for the early diagnosis and treatment of ankylosing spondylitis
.
The symptoms of low back pain and morning stiffness are similar to many diseases and are easy to be misdiagnosed.
Therefore, the HLA-B27 test is very important for the early diagnosis and treatment of ankylosing spondylitis
.
diagnosis
HLA-B27 testing has also become a clinical support diagnosis and an important basis for judging the severity and prognosis of the disease
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In addition, the correlation between spondyloarthropathy (SpA) and HLA-B27 ranges from 70% to 90% to 40% to 50%.
HLA-B27 testing has also become a clinical support diagnosis and an important basis for judging the severity and prognosis of the disease
As for whether HLA-B27 can be diagnosed, this question is actually worthy of discussion
Although many patients have HLA-B27 positive, be careful not that the result of this test is positive, it must be ankylosing spondylitis? Among all HLA-B27-positive people, only 5% to 20% can be diagnosed with ankylosing spondylitis
At the same time, not all blood tests of patients with ankylosing spondylitis showed positive HLA-B27
3.
HLA antigen detection method
HLA antigen detection method
According to the expression characteristics of HLA-B27, common methods used for clinical detection include MLCT Assay, double antibody sandwich enzyme-linked immunosorbent assay (ELISA), magnetic bead enzyme-linked immunoassay (IMS-ELISA), Flow cytometry analysis method (FCM), polymerase chain reaction-sequence specific primer method (SSP-PCR) and real-time fluorescent PCR (qPCR) method, etc.
,
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In general, the flow cytometry analysis method (FCM) to determine the expression of HLA-B27 is simple, easy to operate, sensitive, specific, reproducible, and more suitable for clinical applications
.
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Although studies have confirmed that human leukocyte antigen B27 positive (HLA-B27+) has a strong correlation with AS, the positive rate of HLA-B27 in AS patients is as high as 90%, but the study also found that certain related diseases are also related to HLA-B27, and health The population of HLA-B27 is also expressed
.
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Therefore, HLA-B27+ cannot be used as the gold standard for the diagnosis of AS, but can only be used as a more powerful reference
.
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Therefore, HLA-B27+ cannot be used as the gold standard for the diagnosis of AS, but can only be used as a more powerful reference
.
4.
The relationship between HLA and other diseases
The relationship between HLA and other diseases
In addition, regarding the inheritance of the HLA-B27 gene, the HLA-B27 gene has a 50% chance of being passed on to children, while for HLA-B27-positive children, there is a 20% chance of developing SpA, but HLA-B27-negative children are suffering from SpA.
The possibility of SpA is extremely small
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Furthermore, positive HLA-B27 can indicate that relatives may suffer from this group of diseases, which can often enable potential patients to get early diagnosis and early treatment
.
The possibility of SpA is extremely small
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Furthermore, positive HLA-B27 can indicate that relatives may suffer from this group of diseases, which can often enable potential patients to get early diagnosis and early treatment
.
HLA-B27 is also related to uveitis in ophthalmology, and rheumatism such as psoriatic arthritis, reactive arthritis, inflammatory bowel arthritis, undifferentiated spondyloarthritis and so on
.
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Concluding remarks
Concluding remarksHLA-B27 is important for the diagnosis of ankylosing spondylitis, but it is not the only condition for the diagnosis of ankylosing spondylitis
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HLA-B27 plays a prominent role in the early screening of patients with suspected ankylosing spondylitis
.
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HLA-B27 plays a prominent role in the early screening of patients with suspected ankylosing spondylitis
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Screening
references
references1.
Du Ranran, Wang Shi, Zhang Huobing, Wang Dingquan, Chen Wenru.
Research progress on the relationship between HLA-B27 and ankylosing spondylitis[J].
Marker Immunoassay and Clinic,2018,25(04):589-592.
Du Ranran, Wang Shi, Zhang Huobing, Wang Dingquan, Chen Wenru.
Research progress on the relationship between HLA-B27 and ankylosing spondylitis[J].
Marker Immunoassay and Clinic,2018,25(04):589-592.
2.
Wang Yan.
Application effect of HLA-B27 antigen detection by flow cytometry in the diagnosis of ankylosing spondylitis[J].
Bethune Medical Journal, 2018.
Wang Yan.
Application effect of HLA-B27 antigen detection by flow cytometry in the diagnosis of ankylosing spondylitis[J].
Bethune Medical Journal, 2018.
3.
Chen Huiyi, Chu Weijing, Zhang Huiying, et al.
Comparison of HLA-B27 detection by real-time fluorescent PCR and flow cytometry[J].
Chinese Journal of Laboratory Diagnosis, 2012, 16(12):2251-2254.
Chen Huiyi, Chu detected as Jing, Zhanghui Ying, et al real-time PCR and flow cytometry method compares two methods of HLA-B27 [J] Chinese Journal of Laboratory Diagnosis, 2012, 16 (12):.
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2251-2254 in This message
