Monoclonal antibodies can effectively inhibit the entry of live new coronary pneumonia virus into cells
Monoclonal antibodies can effectively inhibit the entry of live new coronary pneumonia virus into cells
Recently, the team of Professor Qin Aijian/Ye Jianqiang of the School of Veterinary Medicine of Yangzhou University and the team of Professor Bu Zhigao of the Harbin Institute of Veterinary Medicine of the Chinese Academy of Agricultural Sciences, the team of Professor Liu Pinghuang of the School of Veterinary Medicine of China Agricultural University and the team of Ye Lilin of the Institute of Immunology of the Army Military Medical University have cooperated.
cellular & molecular immunology According to Qin Aijian, director of the Key Laboratory of the Ministry of Education, before the outbreak of the new crown pneumonia, the research team has been paying attention to the immune prevention and control research of avian infectious bronchitis virus (IBV), which is the same coronavirus family as the new crown virus
Ye Jianqiang introduced that the universal vaccine is a kind of broad-spectrum vaccine designed by selecting the gene sequence of the low-frequency mutation of the important protective antigen of the virus
The study discovered a broad-spectrum neutralizing peptide derived from the S protein of the new coronavirus and named it P4
The team prepared multiple monoclonal antibodies against P4 polypeptide
The first author of the paper, Dr.
The results of the study show that mice immunized with the recombinant protein can produce antibodies that effectively neutralize the S protein pseudovirus of the new coronavirus pneumonia virus
Ye Jianqiang said that in view of the current emergence of new crown variants and their immune escape strains, such as the discovery of the P4 broad-spectrum protective peptide in this study and the creation of the corresponding neutralizing monoclonal antibody, it is necessary to develop a universal new crown vaccine and Broad-spectrum therapeutic drugs provide an opportunity
It is reported that this achievement has applied for a national invention patent.
Related paper information: https://doi.
https://doi.
org/10.
1038/s41423-021-00778-6
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
