High coffee intake may be associated with a low risk of prostate cancer

Prostate cancer is the second most common cancer and the sixth leading cause of cancer death in men.
estimates that nearly three-quarters of prostate cancer cases occur in developed countries.
since the 1970s, the incidence of prostate cancer has also risen rapidly in some Asian countries, such as China, Singapore and Japan, where the incidence rate has been much lower than in some Western countries.
, the first level of prevention of prostate cancer is a major public health problem worldwide.
coffee is one of the most popular drinks.
because of its worldwide popularity, even small impacts on individual health can have a significant impact on public health.
in industrialized countries, coffee is a major source of caffeine, caffe alcohol and antioxidants.
its many components, such as caffeine, caffeine and glorogenic acid, can potentially affect cancer development through a variety of carcinogenic pathways.
coffee intake was observed to be negatively associated with cancer risk in areas such as the liver, colorectal and breast.
, however, previous studies have reported inconsistent results on the relationship between coffee drinking and the risk of prostate cancer.
although early queue studies have found no link, 15 recent studies in major Western countries, including the United States, Sweden and the United Kingdom, have reported that coffee drinking is associated with a lower risk of local and advanced prostate cancer.
a team study in Japan, an increasingly popular country for coffee, also found a significant negative correlation between coffee drinking and the risk of prostate cancer.
recently, a new paper published on BMJ Open conducted a meta-analysis of these queue studies, a systematic review of the relationship between coffee intake and prostate cancer risk. This is a metadata analysis based on research level data, with no data on individual levels, and no definition of research questions or result measurements.
to use PubMed, Web of Science, and Embase for literature searches up to September 2020, using the following keywords: coffee and prostate (cancer or neoplasm or tumor).
meta-analysis, RR estimates were used to measure the relationship between coffee consumption and prostate cancer risk.
researchers compiled RR estimates for the highest and lowest categories of coffee consumption. the
subgroup analysis was strated by study location, stage of prostate cancer, and potential conferencing factors, including a history of prostate-specific antigen (PSA) testing, family history of prostate cancer, total energy intake, smoking, alcohol consumption, physical activity, body mass index (BMI), or diabetes history.
because PSA testing was conducted after 1986, 32 studies with follow-up periods completed before 1986 were classified as PSA adjustment groups.
to explore the impact of each study on aggregated results, sensitivity analysis was conducted, excluding one study at a time, and then repeating the meta-analysis method.
was eventually included in 16 prospective cohort studies, including 57,732 cases of prostate cancer and 1081,586 cohort members.
you drink coffee, the lower your risk of prostate cancer.
the combined relative risk (RR) for the highest coffee consumption category was 0.91 (95% CI 0.84 - 0.98), I2 s 53.2%) compared to the lowest coffee consumption category.
there is a significant linear trend in correlation (linear trend p-0.006), and for each additional cup of coffee per day, the combined RR is 0.988 (95% CI 0.981 to 0.995).
for local, advanced, and fatal prostate cancer, the combined RRs are 0.93 (95% CI 0.87 - 0.99), 0.88 (95% CI 0.71 - 1.09), and 0.84 (95% CI 0.66 - 1.08), respectively.
found no evidence of bias published in this meta-analysis.
map of the dosage-reaction relationship between coffee consumption and prostate cancer risk, layered by cancer.
advantage of this study is the inclusion of forward-looking cohort studies.
study can minimize the risk of selection and recall bias, which is the main concern of case control design.
addition, a large number of queue members and prostate cancer cases ensure sufficient statistical capacity to detect even small effects.
addition, dose response analysis may further increase the confidence of the study hypothesis and increase coffee consumption linearly associated with a lower risk of prostate cancer.
addition, most studies are of high quality and have a low risk of bias, which further enhances confidence in the current aggregate results.
, the study suggests that drinking more coffee may be associated with a reduced risk of prostate cancer.
further research is needed to explore the potential mechanism of action and active ingredients in coffee.
if this link is further shown to be a causal relationship, men may be encouraged to increase their coffee consumption, potentially reducing the risk of prostate cancer.
1.References: Xiaonan Chen, Yiqiao Zhao, Zijia Tao. Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis. BMJ Open, 2021 DOI: 10.1136/bmjopen-2020-038902MedSci Original Source: MedSci Original Copyright Notice: All noted on this website "Sources" : The text, images and audio and video materials of Metz Medicine or Source: MedSci Originals are owned by Metz Medicine and may not be reproduced by any media, website or individual without authorization, and shall be reproduced with the words "Source: Mets Medicine".
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