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HGF monoclonal antibody is accredited by FDA Fast Track

 Last Update: 2021-10-23
 Source: Internet
 Author: User

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Article source: Medical Rubik's Cube Info

Author: Shi Bei

On September 20, AVEO Oncology announced that the FDA granted the company a fast track designation for the targeting HGF monoclonal antibody ficlatuzumab for the treatment of patients with recurrent or recurrent head and neck squamous cell carcinoma (R/R HNSCC)

Ficlatuzumab (AV-299) is a potent hepatocyte growth factor (HGF) immunoglobulin G1 (IgG1) inhibitory antibody under investigation, which can bind to HGF ligands with high affinity and specificity

In June 2021, the company announced the use of ficlatuzumab as a single agent or combined with EGFR monoclonal antibody cetuximab for relapsed or refractory metastatic head and neck squamous cells that had previously received immunotherapy, chemotherapy, and cetuximab.

Positive results were obtained in the Ficlatuzumab combined with cetuximab group.

Ficlatuzumab combined with cetuximab is well tolerated and has similar expected toxicity to HGF/cMet inhibitors.

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