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Heterogeneous development of beta cells in diabetes-resistant and susceptible mice

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Progressive insulin-releasing beta-cell dysfunction and exhaustion is a hallmark of type 2 diabetes (T2D)

To investigate the mechanism of beta cell loss in T2D, DZD researchers performed single-cell RNA sequencing of islets of Langerhans in two obese mouse strains with different susceptibility to diabetes

In contrast, expression changes in beta cells from diabetes-prone mice suggest metabolic stress and stress in the endoplasmic reticulum

"Our study provides new clues as to why obesity does not always lead to type 2 diabetes

STUDY: Researchers from the German Center for Diabetes Research, Helmholtz Munich and Carl Gustaf of the Carus University Hospital and Medical School in Dresden participated in the study, which was conducted by the German Institute for Human Nutrition Potsdam-Rehbruecke (DIfE)

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