Here are five things you need to know about the safety of the COVID-19 mRNA vaccine!

December 20, 2020 // -- As part of efforts to end the global COVID-19 pandemic, the world's first mRNA vaccine Unprecedented speeds have been made and are now being rolled out, followed by a second vaccine, one by Pfizer/BioNTech and the other by Moderna, marking the first approval of mRNA vaccine technology.
in clinical trials, this new mRNA vaccine has at least 94% effect in preventing people from developing COVID-19, but what about the safety of this new technology? The researchers suggest the following five points: 1) mRNA vaccine technology is not a new technology such as inactivated polio vaccine or most influenza vaccines use inactivated viruses to induce the body's immune system to respond to disease-inducing pathogens.
other vaccines, such as the hepatitis B vaccine, are injected with a single protein made by organisms to cause a similar immune response.
, however, the mRNA vaccine deceives the host to create the virus protein itself, which in turn causes an immune response.
although the mRNA vaccine made by Pfizer/BioNTech is the first mRNA vaccine to complete all clinical trial stages and be licensed, the technology has been around for some time.
the same mRNA technology for human trials of cancer vaccines has been ongoing since 2011, and if there is a real problem with the technology, researchers will now be able to see it.
because the technology can be deployed quickly and clinical trials have been successful, the mRNA platform has become an important way to help scientists cope with future outbreaks and epidemics.
Photo Source: pexels.com/Gustavo Fring, licenced pexels licence2) mRNA vaccine does not change the body's DNA Some people are worried about the mRNA vaccine, they think it may change human DNA, but this idea is completely wrong and has no scientific basis.
mRNA vaccine does not enter the nuclei (where DNA is located).
the mRNA vaccine enters human cells, it degrades rapidly and stays in the body for only a few days.
that's why people need two vaccinations to have the best immune response in the body.
3) the very special SARS-CoV-2 virus has a very complex structure, and different parts of the virus can induce the body's immune system to produce different antibodies to mediat the virus.
If an unvaccinated person is infected with the virus, the body produces antibodies that block the virus from entering human cells, and they may also produce antibodies that have little impact;
mRNA vaccine is very specific and can be designed to target only the body's immune response to viral tingling proteins, which are an integral part of the viral membrane and can properly invade host cells.
to ensure this fact, researchers are carefully monitoring the vaccine for unnecessary immune responses.
Goldman, a researcher, says the COVID-19 vaccine has so far not shown this, but it may be important to ensure that the vaccine-induced immune response is focused on viral prickly proteins.
4) Trials of vaccines that have not been stolen during clinical trials and approval are conducted in stages, first in animals and then in human trials in phases I, II and III.
phase 3 clinical trial of the Pfizer/BioNTech vaccine, involving 40,000 people, begins in July 2020 and future researchers will continue to collect data on vaccine efficacy and safety over a two-year period.
Goldman, said most of the safety issues affecting a large number of vaccines would occur within two months.
However, after vaccinations for millions of people, people may experience very rare side effects that cannot be predicted in clinical trials, so researchers and regulators will be watching the spread of the vaccine closely, especially for mRNA vaccines, which are developed based on innovative technologies.
regulator's review of COVID-19 vaccine trial data is faster than usual, and it will be reviewed in a rolling manner, not just after the trial is completed, but this does not fundamentally change the rules, so there is no problem of stealing materials in terms of safety.
This process is faster than usual, because now researchers have built an mRNA platform (a way to get viral mRNA into the body) for cancer and other vaccines that are being tested, which means that once the virus's genome sequence is shared, the researchers can put it into practice as soon as it is shared.
of course, companies and governments also take the risk of producing large quantities of vaccines even before the first phase of the trial is completed, which means that once the results are available, they can begin large-scale human trials immediately.
5) The vaccine works in part by inducing inflammatory reactions that trigger the function of the immune system by inducing local inflammatory reactions.
means that many people experience pain at the injection site and sometimes fever and discomfort within a day or two of the injection, which is normal.
of course, the researchers haven't done enough publicity at the moment.
in November, researchers in 15 countries found that 54 percent of the population was concerned about the possible side effects of the COVID-19 vaccine.
on the first day of mass vaccinations in the UK, two patients with a history of severe allergies developed adverse reactions, after which UK regulators updated their recommendations to make it clear that people with a history of drug or food allergies should not be vaccinated.
In clinical trials, 0.63 percent of people developed allergic reactions after being vaccinated with the Pfizer/BioNTech vaccine, and 0.5 percent developed allergic reactions after being given a placebo;
() Reference: PFIZER AND BIONTECH PHASE 3 OF COVID-19 VACCINE CANDIDATE, MEETING ALL PRIMARY EFFICACY ENDPOINTS2: Five things you need to know: mRNA vaccine safetyby Horizon Magazine, Alex Whiting, Horizon: The EU Research and Innovation Magazine<!--/ewebeditor: page->