Helicobacterzyb has a new star: Dansan extract to protect the stomach performance is not bad

The latest global cancer data show that of China's 4.57 million new annual cancer cases, 480,000 new cases of stomach cancer, accounting for 10.8%, ranked in the top three.
in China, which has a high incidence of stomach cancer, helicobacter pyridosis infection rate is as high as 50%, and the problem of antibiotic resistance is becoming more serious, leading to a decline in eradication rate.
recently, Professor Bi Hongkai of Nanjing Medical University's School of Basic Medicine successfully screened for a new drug candidate for drug resistance helicobacter pylbocobacteria, DD hydrodynasterone I.
Dihydrodantoxone I has the advantages of high-efficiency and rapid killing of Helicobacterium, anti-Helicobacterrobacteria biofilm, safety and hard resistance, and is expected to enter preclinical research as a promising anti-Helicobacterium candidate drug.
results were published online in antimicrobials and chemotherapy, an international leading antimicrobial journal.
The new value of ginseng was discovered three years ago under a microscope with a length of only 2.5 to 4 microns and a width of only 0.5 to 1 micron of "teeth dancing claws" of the spiral-curved bacteria - Helicobacter pyrethroids, not only can lead to acute and chronic gastritis and stomach, tweenome ulcers and lymphatic gastric lymphoma and other diseases, but also with stomach cancer and liver cancer outside the intestines, diabetes.
combination therapy containing two antibiotics is a common treatment in China, but traditional treatment methods can not "root out" Helicobacterrobacteria.
treatment failure rate for traditional therapies is about 10%, with some patients developing diarrhea or gastrointestinal bacteriocycysis disorders.
are allergic to penicillin, there are fewer antibiotics to choose from.
, long-term use of antibiotics will make bacteria resistant, making antibiotics less effective, completely unable to achieve eradication effect.
" Bi Hongkai said: "Bacterial resistance can also spread to each other, bacteria resistant to certain antibiotics, but also to other antibiotics, and resistance can also be between different bacteria, the body's normal bacterium and pathogenic bacteria, through the spread of drug-resistant genes to each other, making bacterial resistance complex."
" Helicobacter pyridobacteria in the resistance to enemy "invasion", but also cunningly to form a "protective cover" for themselves, that is, biofilm, and biofilm on antibiotics will have resistance, resulting in increased resistance, affecting the effectiveness of treatment, reduce the cure rate.
1994, the World Health Organization classified Helicobacter pyridobacteria as a class I carcinogen because it plays a leading role in the development of stomach cancer, and how to eradicate this "health killer"? In early 2017, Bi Hongkai's team made a breakthrough through preliminary experiments--- Dansan.
Dihydrodansin ketone I can destroy helicobacter pylofoxone biofilm at the same time, kill the attached bacteria Dansan is one of the most widely used live blood, chemical traditional Chinese medicine in China, its fat-soluble extract is ginseng ketone compounds, including dansan ketone I, dihydrodansin ketone, dansin ketone IIA, resuscantone and more than 30 monoliths.
have a variety of pharmacological effects, such as anti-cancer, anti-positive bacteria, anti-inflammatory, estrogen-like activity and cardiovascular protection, but the anti-Helicobacterium effect has not been reported.
", we conducted cell-level screening of more than 1000 kinds of Chinese medicine monoliths, and finally determined that the effect of helicobacter pylepsis was best in the monolithicide I monolithicide in Dansan.
cell tests,
found that when the concentration of dhydrodansinone I was 0.125 to 0.5 micrograms per milliliter, it was available to inhibit the growth of multiple Helicobacter pylus strains, including antibiotic-sensitive and multi-drug-resistant strains.
" Bi Hongkai said that dihydrodansinone I also has a very good anti-sterilization effect on helicobacter pylene in the biofilm, and in the process of continuous transmission of Helicobacter pylene did not produce resistance to dihydrodansinone I.
Bigger surprise is that "dihydrodansinone I in the killing of Helicobacterium, not only can destroy the biofilm, but also can kill the bacteria attached to the biofilm, can be said to play a 'root up' role."
" In mice, dhydrodansinone I is more efficient than traditional drugs to make the results more accurate, Bi Hongkai team also in mice screening experiments to further determine the effect of DXDSone I on Helicobacter pylhobacteria.
Bi Hongkai introduced, in the experiment, two weeks after the mouse infection with Helicobacter pylus, the researchers randomly divided the mice into three groups, namely, omeprazole and hydrodanazine I combined administration group, standard triple program administration group, phosphoric acid buffer control group, and then for 3 consecutive days, once a day to the mice.
, the researchers then calculated the amount of Helicobacterrobacteria planted in the mice's stomachs.
" mouse experiment lasted two months, and the results showed that the combined administration group of omeprazole and hydrodanazine I had higher efficiency in killing Helicobacterium than that of the standard triple programme group.
," Bi Hongkai said.
will I be able to enter the "ordinary people's homes"? Bi Hongkai stressed that Dansan can not be directly used to prevent and treat Helicobacter pylepsis infection, and its monohydrodamine 1, from the production of clinically available drugs there is still a long way to go.
he said that the next step they will continue to carry out research on the mechanism of the role of bihydrodansinone I, improve the anti-Helicobacteriobacteriosis pharmacology and toxicology research.
"the future is still a long way, and we hope that companies will participate in preclinical research to continue this research for the benefit of more patients with stomach diseases."
" Editor: Wang Yu (internship) Review: Tube Jingjing 0-10-1 (Print) "Close"