Helicobacter pylori infection increases the risk of ischemic stroke

Ref: Wang ZW,et al.
JNeurol2012 Dec;259 (12): 2527-37doi: 10.1007/s00415-012-6558-7Epub 2012 Jun 12)Helicobacter pylori (H.pylori) is a Gram-negative spiral bacteria that can cause a variety of diseases, such as chronic gastritis, peptic ulcers and stomach cancerStudies have shown that H.pylori infections may affect the incidence of ischemic stroke (ischemic stroke, IS)IS accounts for more than 50% of all strokes, and inflammation and inflammation-related atherosclerosis play a role in IS's progression and prognosisChronic H.pylori infection can lead to an increased incidence of atherosclerosis, which in turn develops into ISTo confirm that chronic H.PPycobacter infection is the cause of IS, epidemiological studies have explored the correlation between chronic H.pylori infection and IS by detecting H.pylori antibody lgG (anti-H.pylori lgG), anti-Helicobacter pylori antibody (anti-CagA lgG) or13Cexhalation testsZhong Wei Wang of the First Affiliated Hospital of Henan Xinxiang Medical College, including The Meta Analysis, used Meta analysis to assess the correlation between chronic H.pylori infection and IS, and to compare the effectiveness of the three tests, published in the December 2012 issue of J Neurol authors retrieve and screen compliant documents and manually review the documents in the Medline database from January 1950 to January 2012 and embase from January 1966 to January 2012 through the keywords Helicobacter pylori, H.pylori, Cag A, stroke, risk, risk, and change, and from January 1916 to January 2012 The inclusion must be: (1) case control design and published in English studies; (2) the study of the correlation between H.pylori and IS incidence through anti-H.pylori lgG, (2) anti-CagA lgG, or 13 C exhalation tests for H.pylori and IS incidence; (3) the diagnosis is explicitly IS; and (4) adequate data must be provided A total of 13 studies, 4041 patient data, case control analysis of eligible patients, including anti-H.pylori lgG, anti-CagA lgG and 13 C exhalation test studies were 10, 4 and 4 respectively The newcastle-Scale Ottawa (NOS) scale was used to verify the raw data quality, calculate the combined OR value and 95% CI value, and assess the relationship between H.pylori infection and the risk of IS the results of the study showed that the positive test of anti-H.pylori lgG, anti-CagA lgG and 13 C the positive test was significantly correlated with the increase in the incidence of IS; 1.21-2.11, P-0.001; anti-CagA lgG positive and 13 C exhalation test positive and 13 C exhalation test negative, no difference in predictive effect .OR,1.65, 95% CI 1.11-2.47, heterogeneous test P-0.17 In addition, the authors found that anti-H.pylori lgG positives were associated with the risk of IS from atherosclerosis and aminor apathy, but not to psychogenic IS , chronic H.pylori infection significantly increases the risk of non-cardiogenic IS Anti-CagA lgG detection is more effective in predicting the occurrence of IS than the anti-H.pylori lgG and 13 C exhalation tests (Xinxiang Medical College Li Xinxiao compiled, Fudan University affiliated Huashan Hospital Professor Wang Zhiqiu review, "Outside the God Information" editor-in-chief, Fudan University affiliated Huashan Hospital Chen Jicheng Professor Final Review) related review