Helicobacter pylori back pot? Turns out it's the number one "murderer" of stomach cancer.

original title: Helicobacter pylori back pot? It turned out to be the number one "killer" of stomach cancer stomach cancer is the fifth most common cancer in the world, and the third leading cause of cancer death saucy worldwide, seriously threatening human health. According to the National Health And Seijsance (2018 edition) data, the world's annual new cases of gastric cancer about 1.2 million, China accounts for about 40% of them, rough estimates, China's annual new gastric cancer patients nearly 500,000 people, equivalent to nearly 1400 people per day.recently, a 22.3-year study by a research team from Peking University Cancer Hospital involved 3,365 local residents in Linyi County, Shandong Province, to explore the link between lifestyle factors and the incidence and mortality of stomach cancer.found that the
of Helicobacter pylori eradication treatment, the combined intervention of vitamins and garlic supplements, is related to a long-term decline in the incidence and mortality of stomach cancer, and
, the study's latest second analysis found that
smoking is the number one "killer" of stomach cancer, resulting in a 72% increase in the incidence of stomach cancer, a 101% increase in mortality
. The study was published online at JAMA Network Open.Figure 1: The study published online in JAMA Network Opento know that the so-called stomach "killer" of Helicobacter pylori, the risk of stomach cancer is 1%, and smoking actually increased the incidence of stomach cancer by 72%, it seems that for so many years, it is helicobacter pylori back pot ... So, the incidence of stomach cancer is so high, around the smoking people so many, how can I protect myself? How to persuade the old smokers around to quit smoking? Don't worry, look down, the following data, in persuading old smokers to quit smoking, you must use it!1long-term garlic to help reduce the death rate of stomach cancer by 34%in 1995, researchers in Linyi County, Shandong Province, launched a Shandong intervention trial to assess the effects of helicobacter pylori eradication treatment (amoxicilinin and omeprazole) for 2 weeks, vitamin supplements (vitamin C/E) and garlic supplements 7.3 years on stomach cancer.Why didchoose Linyi County, Shandong Province? Because this is only 1,834 square kilometers, with a population of 880,000, it is almost the most common incidence of stomach cancer in China (you know China is a big country with stomach cancer, accounting for about half of the total number of cases in East Asia in 2017).Diagram 2: Study FlowAfter 22.3 years of follow-up, the researchers found that
The
of Helicobacter pylori eradication treatment (OR 0.48; 95% CI 0.32-0.71)
and vitamin supplements
(OR 0.64; 95% CI 0.46-0.91)
significantly reduced the risk of long-term
in gastric cancer, and garlic supplements were not significantly effective.second,
Helicobacter pylori eradication therapy, vitamin supplementation and garlic supplements all had significant effects in preventing death from stomach cancer, with a reduction of 38%
(HR 0.62; 95% CI 0.39-0.99),
52%
(HR 0. 48; 95% CI 0.31-0.75),
34%
(HR 0.66; 95% CI 0.43-1.00)
of the infant cancer mortality rate
, suggesting that lifestyle factor interventions may prevent stomach cancer.Figure 3: The relationship between helicobacter pylori eradication therapy, vitamins and garlic supplements and the incidence and mortality of stomach cancerunique, the story of garlic prevention of stomach cancer, 2012, Sichuan University Huaxi Hospital gastroenterology experts in gastroenterology published in Gastroenterology Studies have confirmed that organic sulfur compounds in onion vegetables such as garlic and onions can inhibit helicobacter pylori in the gastrointestinal tract, thereby reducing the incidence of stomach cancer, and
increase 20g of onion garlic per day can reduce the incidence of stomach cancer by 10%
., however, the study also points out that the claim that garlic prevents stomach cancer has some credibility, but it is not comprehensive. Garlic can only prevent stomach cancer caused by Helicobacter pylori infection to a certain extent, and cannot be 100% prevented.in people at high risk of stomach cancer with Helicobacter pylori infection, do lifestyle factors affect the prevention of nutritional supplements?
to this end, the latest secondary analysis of the Shandong Intervention Trials focused on the effects of tobacco, alcohol and diet on stomach cancer, and further tested the interaction between lifestyle factors and two nutritional supplements.2smoking increased the death rate from stomach cancer by 101%, equivalent to double thestudy showed that smoking in the
increased the incidence of stomach cancer by 72%
(OR 1.72; 95% CI 1.003-2.93), and doubled the mortality rate by 101%
(HR 2.01; 95% CI 1.01-3.98),
. This association was particularly pronounced in the positive population of Helicobacter pylori, with
incidence and mortality increased by 88%
(OR 1.88; 95% CI 1.01-3.47)
and 115%
(HR 2.15; 95% CI 1.01-4.61), respectively., the researchers believe that smoking increases exposure to carcinogens and N-nitrocompounds, which may partly explain the increased risk of stomach cancer in smokers.Figure 4: The relationship between lifestyle factors and the incidence and mortality of stomach cancernot quit smoking, eating more garlic is also a white tie-upfurther analysis of the effects of lifestyle factors on the prevention effect of nutritional supplements, the data show interesting results,
smoking may also offset the nutritional supplement's preventive benefits of stomach cancer.
in people who had never smoked, vitamin supplements were more effective in preventing death from stomach cancer than those who smoked, with a 65 percent lower risk (HR 0.35; 95% CI 0.15-0.85).Table 1: The effect of lifestyle factors on the preventive effect of nutritional supplements in fact, as early as 2019, the Lancet Journal published "1990-2017 global 195 countries and regions of the gastric cancer burden analysis study" pointed out that the main cause of gastric cancer can be attributed to high sodium diet and smoking, globally, due to gastric cancer caused by disability-adjusted life year (DALYs) 38.2% attributed to high sodium diet, 17.1% of men.of course, not only stomach cancer, smoking also increases the risk of throat cancer, liver cancer, bladder cancer, lung cancer, esophageal cancer, oral cancer and other cancers.said so much, smoking, or early quit it, 3smoking can not, that can drink?Although the correlation between alcohol consumption and stomach cancer was not significant in the study,
garlic supplements showed preventive effects only in people who never drank alcohol, with a 67% reduction in stomach cancer mortality
(HR 0.33; 95% CI 0.15-0.75), while the benefits of garlic supplements were not observed in the drinking population, and the association was more pronounced in participants who were positive about Helicobacter pylori.researchers believe this is because garlic contains propylene-based sulfur compounds that can fight cancer by inhibiting the activation of carcinogens, regulating the metabolism of carcinogens, inhibiting the formation of DNA compounds with carcinogens, and alcohol can cause direct damage to DNA, trigger inflammation, affect the health of the stomach flora, and alcohol intake may change the cancer-proof benefits of garlic.Table 2: In the Ausobacillus infection subgroup, the relationship between garlic supplements and the incidence and mortality of stomach cancer about alcohol cancer, as early as 2017, the American Society of Clinical Oncology (AsCO) issued a statement stating that
alcohol is an important carcinogen
. In 2018, a study of the Global Burden of Disease, published by Lancet, noted that there is no safe drinking dose, and that even small amounts of alcohol increase the risk of cancer. 4 vitamins are good, but don't be greedy in order to give lifestyle intervention gastric cancer prevention more accurate guidance, the researchers continue to broaden the observation indicators to stomach inflammation and precancerous lesions. study found that between 1995 and 2003, 42.9 per cent of participants developed stomach lesions. Analysis of the relevant data found that in the population with low intake of fresh fruits and vegetables (81 kg/year, about 222g/day), vitamin supplementation can be a preventive effect, reducing the risk of stomach lesions by 20%, while
in the population with sufficient fruit and vegetable intake, vitamin supplements appear to be somewhat counterproductive, in the population with high erasing fruits and vegetables (81 kg/year), vitamin supplementation increases the risk of gastroenteremia only
. in short, quit smoking and alcohol, eat more fresh fruits and vegetables and garlic, maintain a good attitude, away from stomach cancer!
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