Heilongjiang University of traditional Chinese medicine put forward and confirmed the new hypothesis of Chinese medicine and taste theory and won the second prize of 2013 National Science and Technology Progress Award

Professor Kuang Haixue, born in 1955, Ph.D of Meiji Pharmaceutical University, Japan, is currently president and doctoral supervisor of Heilongjiang University of traditional Chinese medicine, leader of Chinese medicine discipline of national key discipline, national famous teacher of ordinary colleges and universities, national excellent scientific and technological worker, member of national pharmacopoeia committee, and serves as teaching guide of Chinese medicine specialty in Colleges and Universities under the Ministry of education Chairman of the committee, chairman of the Specialty Committee of traditional Chinese medicine chemistry of the World Federation of Chinese Medicine Societies, executive director of the Council of Chinese Medicine Societies, vice chairman of the Specialty Committee of traditional Chinese medicine natural medicine of Chinese Medicine Societies, etc Professor Kuang Haixue has been engaged in the research of Chinese medicine and its compound effective substance basis, Chinese medicine property theory and innovative drugs for more than 30 years He has successively presided over more than 20 national and provincial scientific research projects, such as the national 973 Plan Project and the National Natural Science Foundation project, as well as a number of application and development research projects, and has made a number of research achievements with important theoretical value and application value In recent years, it has won two second prizes of national science and technology progress, one first prize of Chinese Association of integrated traditional and Western medicine, and four first prizes of Heilongjiang provincial government for science and technology progress The two doctoral theses under its guidance have been awarded national excellent doctoral theses Professor Kuang Haixue of Heilongjiang University of traditional Chinese medicine presided over and completed the project "construction and application of theoretical research mode of traditional Chinese medicine property" and won the second prize of 2013 National Science and technology progress This research breaks through the traditional "one medicine, one nature" theory of traditional Chinese medicine, creatively puts forward a new hypothesis of "one medicine, one medicine, one taste, one y (Y ≤ x)", and confirms the objectivity of the hypothesis through research, which is an original innovation with great scientific significance and application value The theory of traditional Chinese medicine sexual taste, which is mainly composed of cold, hot and cool "four Qi" and sour, bitter, sweet, pungent and salty "five taste", is the core of the theory of traditional Chinese medicine, and also the basis and principle of clinical Chinese medicine Professor Kuang Haixue led the research group, through more than ten years of intensive research, for the first time through experimental research, clarified the nature of Chinese medicine sexual taste and the relationship between four and five flavors, that is, Chinese medicine (including sexual taste components or compounds) has both sexual (gas) and taste; five flavors are mainly related to the physical efficacy of Chinese medicine, and four characteristics are mainly related to the energy metabolism and material metabolism that affect the body; four characteristics can be passed through The influence of traditional Chinese medicine on energy metabolism and material metabolism was evaluated This study explored a new method of theoretical research on the nature and taste of traditional Chinese medicine which can be separated and combined; established a prediction model of cold and hot nature of traditional Chinese medicine based on metabonomics biomarkers, combined the modern method with the traditional evaluation method of nature and taste, enriched and improved the evaluation method of the four properties of traditional Chinese medicine, which can be effectively used for the evaluation of cold, hot, warm and cold four properties of traditional Chinese medicine; coagulated It is of great application value to train and clarify a group of new concepts and connotations related to the theory of traditional Chinese medicine sexual taste, and to build a new model for the theoretical research of traditional Chinese medicine sexual taste Using the above research model, the research group first clarified the material basis of the bitter and bitter taste of Evodia rutaecarpa and ephedra respectively; it was confirmed that the bitter and bitter taste of Evodia rutaecarpa were both warm, while the bitter taste of Ephedra was warm, and the bitter taste (the material basis was the polysaccharide component with strong immunosuppression production found by the research group) was cool For the first time, it was found and proved that Flos Carthami is not a traditional single traditional Chinese medicine, but a compound Chinese medicine with both bitter and pungent taste It was clarified that the material basis of its pungent taste is alkaloid component, which is warm Its bitter taste has the effect of clearing away heat and wind, detoxification and antipruritic The material basis is solanacerolactone and flavone component, which is cool Based on the combinability of Zuojin Pill and Evodia decoction, it is proved that the components of Evodia officinalis can replace the pieces of Evodia officinalis and play a corresponding role in the prescription This research model can also be used as a new way of new drug discovery based on the theory of traditional Chinese medicine Based on this, the research group has found the new taste (bitter taste) of Flos Lonicerae and proved that it has a unique therapeutic effect on psoriasis, clarified the material basis of bitter taste, separated and determined 61 compounds (25 are new compounds); constructed a multidimensional evaluation system for drug treatment of psoriasis, which provides a solution to the problem of developing new drugs for treatment of psoriasis but lacking pharmacodynamics and mechanism of action evaluation model Demonstration On the basis of clarifying the series of pharmacological actions related to the treatment of psoriasis, five kinds of HaCaT cell models and animal models of psoriasis like lesions were used to study the mechanism of action It was found that the ester and flavonoid components and their monomer compounds in the bitter substance base of Flos Lonicerae were different in different pathological models induced by DMSO, EGF, IFN - γ, TNF - α, etc It is complementary and reveals the mechanism of action and interaction of various levels of taste substance basis of Flos Lonicerae from various angles It has completed the preclinical study of five kinds of new drugs, and the new hospital preparation "Flos Lonicerae capsule" has been used in the treatment of psoriasis patients, with a total effective rate of 90.75%, of which the recovery rate is 65.93%, and no toxic and side effects, and has achieved significant social benefits For the first time, it was found that acidic polysaccharide, the basic substance of Ephedra bitter, had strong immunosuppressive effect, and had good therapeutic effect on allergic asthma, rheumatoid arthritis and chronic nephritis The chemical structure, structure-activity relationship and mechanism of 14 kinds of new acidic polysaccharides were clarified The scientific interpretation of the understanding of ephedra taste effect of traditional Chinese medicine was also made, which opened a new way for the reuse of Ephedra resources Path The theory of traditional Chinese medicine property is an important part of the theory of traditional Chinese medicine, in which the theory of traditional Chinese medicine property is the core This new hypothesis proposed by Professor Kuang Haixue not only follows the basic theory of traditional Chinese medicine, but also carries out important academic thought innovation on this basis It clarifies and deepens the understanding of the essence and connotation of traditional Chinese medicine taste with modern scientific research technology, enriches the content of traditional Chinese medicine property theory by clarifying the internal fine structure of traditional Chinese medicine property, and constructs the new drug development based on traditional Chinese medicine property theory The new way and new drug research and development mode have great and far-reaching influence on the academic development and clinical application of traditional Chinese medicine.