Heavyweight article focuses on new results from cancer metastasis research!

In this paper, the small editor compiled a number of important research results, to read the scientists in the field of cancer metastasis research achievements, share to everyone! Photo Credit: CC0 Public Domain 1 EMBO Mol Med: New Discovery! A new antibody molecule is expected to significantly inhibit cancer metastasis: 10.15252/emmm.201911164 receptors arranged on the surface of the cell layer inside the blood vessels may stimulate the formation of new blood vessels in tumors and accelerate cancer metastasis, a recent report in the international journal In a study published in EMBO Molecular Medicine, scientists from the German Cancer Research Center and other institutions successfully blocked the receptor's function using a special antibody, effectively inhibiting metastatic growth of cancer in breast or lung cancer mouse organisms, and in animal experiments, researchers have found a new mechanism to slow the spread of cancer cell metastasisLike healthy tissue, tumors depend on nutrients received through the blood to survive, however, because cancer cells will multiply rapidly and tumors will grow rapidly accordingly, the problem arises, i.enew blood vessels do not appear at the same time, in addition, new blood vessels are also the transport route for cancer cells to reach the far-end metastasis organs, the goal of the researchers in cancer therapy research is to inhibit the occurrence of tumors, that is, the formation of new blood vessels, thereby depriving the tumor of nutrients acquired and slowing cancer metastasisNature Sub-Journal: New drug successfully stops cancer from metastasis! In a recent study published in the international journal Nature Communications, researchers from the Francis Creek Institute found a drug that is well-tolerated to patients that prevents cancer from relapsing in miceOne of the biggest challenges in cancer research is to prevent cancer recurrence in patients who have already been treatedOne reason for these relapses is that some cancer cells survive and grow into new tumorsIn the article, the researchers showed quisinostat, an experimental drug that can prevent tumor growth and the spread of human cancer cells that survive in culture after initial treatment in living miceThe drug works by increasing the number of a protein called histone H1.0 in tumor cellsThis protein blocks the replication of cancer cells, which in turn prevents the growth of tumorsWhen the team tested the drug on tumors in mice, it stopped the tumor seamountAlso, when tested on cells taken from patients with breast, lung or pancreatic cancer, cancer cells are also trapped in a non-divided statePNAS: Unmasked! Cancer cells may be able to use special copper-binding proteins to transfer! Doi: 10.1073/pnas.1910722117, in a study published in the international journal Proceedings of the National Academy of Sciences, scientists from the Chalms University of Technology in Sweden and other institutions found that a protein found in breast cancer cells called Atox1 or involved in the metastasis process of cancer cells, the protein may be used as a potential biological marker to help assess the severity of the disease and develop new target drugsBreast cancer is the most common type of cancer in women worldwide, and early diagnosis and treatment are critical to improving survival rates, and most breast cancer-related deaths occur when cancer cells leave primary tumor lesions and move to other parts of the patient's body, such as bones, liver or lungs, and researchers do not know the molecular mechanisms behind cancer cells migrating to other parts of the bodyPrevious studies have shown that, like other cancers, breast cancer occurs with higher levels of copper in blood and tumor cells, but the role of this extra copper in cancer cells is not clear; copper and other metal ions in the body can be obtained through food, and it is essential to maintain the body's normal physiological function, free copper ions are toxic, so the body's copper ions must be combined with proteinsNat Cell Biol: Breast cancer cells may be able to shift their metabolic strategies to the metastasis: 10.1038/s41556-020-0477-0 Recently, scientists from the University of California and other institutions have developed new strategies to prevent cancer cells from spreading to other organs of the body and effectively reduce breast cancer mortalityThe researchers say breast cancer cells can convert metabolic strategies to shift, not glucose as energy, but with limited use of mitochondrial metabolism; DrLawson said this may have important potential clinical implications because drugs that target mitochondrial metabolism or can effectively inhibit the spread of cancer in breast cancer patients; tumors are often thought to contain mitochondria with abnormal function and are often maintained by anaerobic glucose solution or Wahlberg metabolism, a theory that is challenged by this study, which shows that cancer cells can use mitochondrial metabolism to spread during breast cancer Nat Mater: Researchers from the Francis Crick Institute have found a key mechanism for controlling the structure of the tissue that may help identify drugs that make cancer cell disease more difficult to spread, according to a recent study published in the international journal Nature Materials The study explains the mechanisms that lead to organizational changes Using experimental and computational biology, these studies have determined how cell-to-cell collisions can help create different organizational structures Some of these structures help spread the cancer, and the authors have also found drugs that inhibit the process All tissues in the body contain protein stents that maintain their structure, which degrades as people age, leading to signs of aging such as wrinkles Cancer cells can destroy the shape of the stent, creating an organizational structure and entering surrounding tissue from the tumor in a variety of ways Cancer cells use these superhighways along them to spread to new areas; however, while we know that these superhighways are associated with the development of cancer, little is known about the mechanisms that control the formation of these tissues Photo Source: NIH 6 Cancer Cell: RingRNA Limits Metastasis of Skin Cancer: 10.1016/j.ccell.2019.12.007 A new study finds that a mysterious genetic material can inhibit the spread of skin cancer cells, but as they mature, they tend to be lost The new study was published recently in the journal Cancer Cell Often, DNA is converted into RNA and then into proteins with cellular functions Although most RNAs are linear molecules, when their ends circulate and attach, some form circles Cyclornarna (circRNA) does not encode proteins, but is part of a complex regulatory system, but its function remains unclear The study, led by researchers at NYU Grossman School of Medicine at NYU Grossman School of Medicine, is the first to show that a ring-shaped RNA called CDR1as can prevent the malignant spread of melanoma, which its absence promotes An analysis of human melanoma tissue also showed that elevated levels of CDR1as were associated with increased survival rates Melanoma is the deadliest type of skin cancer, and invasive spread or metastasis of cancer cells is the leading cause of death in melanoma patients Cancer cells are produced from normal cells because of genetic errors, but changes in DNA do not fully explain how cells spread This study provides new insights into the aggressive behavior of melanoma and reveals for the first time the role of circRNA as a metastatic inhibitor 7: Cancer cells promote breast cancer metastasis by increasing the production of ribosome proteins: 10.1126/science.aay0939 hormone receptor-positive breast cancer can spread throughthe body through circulating tumor cells (CCs) in the blood, eventually reaching far end of the body and forming metastatic tumors; in a new study, researchers from the Massachusetts General Hospital Cancer Center and Harvard Medical School reported that increased ribosomes increase the potential for metastasis Ribosomes are protein manufacturing plants found in every living cell Their observations showed that a CTC subgroup of blood-enriched breast cancer patients had higher levels of ribosomal protein, and their presence was associated with increased disease aggressiveness and poorer clinical outcomes Importantly, the findings also suggest that a combination of targeted drugs that disrupt ribonucleic function and inhibit cancer cell growth slows the spread of breast cancer in mouse models 8: New results! Two cancer-promoting genes, or collaboration, can work together to promote cancer metastasis: 10.7554/eLife.50731, a recent study published in the international journal eLife, scientists from Stanford University and other institutions found that the disease is called MYC And TWIST1's cancer-promoting genes may "pull together" the body's immune cells to promote the spread of cancer cells, blocking this critical step or can effectively inhibit cancer progression, and the results may help clinical researchers identify the risk of cancer metastasis in patients, which could hopefully help develop new treatments that inhibit cancer metastasis Researcher Dr Renumathy Dhanasekaran said that many cancer-related deaths are caused by cancer metastasis, but there is no effective way to curb cancer metastasis, and the main goal of this study is to understand how cancer-promoting genes promote cancer metastasis and how research can be used to identify targeted therapies that inhibit cancer progression In the article, the researchers genetically engineered mice to express both THEMYC and TWIST1 genes, and the researchers found that both of these major cancer-promoting genes trigger cancer metastasis Nat Commun: Fibroblasts or doi, which promotes the growth and metastasis of breast cancer: 10.1038/s41467-019-12370-8 Connective tissue cells called fibroblasts are essential for the body to recover from injury and illness, and when fibroblasts perceive tissue damage, they are attracted to be drawn to tissue damage In a recent study published in the international journal Nature Communications, researchers from Tel Aviv University in Israel found that fibroblasts play a destructive role in the development of breast cancer, in which fibroblasts respond to tumor-damaged tissue and induce inflammation that promotes tumor growth and metastasis in the lungs Researcher Professor Neta Erez said: 'For the first time in this study, we found that in breast cancer, these fibroblasts activate a misguided wound healing response and respond to tissue damage caused by cancerous growth; The researchers point out that the inflammatory response of fibroblasts not only promotes the growth of local tumors in the breast, but also creates a suitable "habitat" for the metastasis of the cancerous lungs, which are activated and, when activated, recruit immune cells and affect vascular health; Cell: Revealing prostate cancer bone metastasis by producing TGF-beta immune therapy mechanism doi: 10.1016/j.cell.2019.10.029 In a new study, researchers at the MD Anderson Cancer Center at the University of Texas in the United States report that prostate cancer that spreads to the bones causes bone tissue damage, which in turn hinders the development of T-cells, which undermines the effectiveness of immunoastapion inhibitors, after all, T-cells are critical to the success of treatment The findings shed light on why immunotherapy has largely failed to treat bone metastasis in prostate cancer, and suggests that this combination of resistance may be reversed The findings were published in the journal Cell Their findings also highlight the need to look at metastatic cancer in a different light; researchers say we tend to think of stage 4 disease as uniform, but not always We need to think more about the immune microenvironments at different transfer sites in order to take into account the different immune responses in these microenvironments when we develop treatments The researchers found that bone damage caused by tumors led to a large number of conversion growth factors,tGF-beta, a protein that causes auxiliary T cells (Th cells) to polarize into Th17 CD4 cells, rather than the Th1 CD4-effect cells needed to trigger an anti-tumor immune response (BioValleyBioon.com) Bio Valley For More Great Counts! 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