Heavyweight article focuses on new advances in body inflammation research!

In this article, we've compiled new recent achievements in the study of inflammation in the body and learned with you! Photo Credit: CC0 Public Domain 1: Brain: Scientists reveal molecular association between inflammation of the body and parkinson's disease Doi:10.1093/brain/awaa246 In a recent study published in the international journal Brain, scientists from the University of Luxembourg and others The study, which revealed a link between inflammation and specific genetic mutations in the body in patients with Parkinson's disease, found that two biomarkers could be used to assess the status and progression of Parkinson's disease, and the results suggest that anti-inflammatory drugs are used to target the processes that affect the body's immune system or potentially affect the disease (at least some patients).
About 15% of Parkinson's disease cases are related to known genetic backgrounds, with mutations in the Parkin and PINK1 genes being the most common causes, so revealing the cellular mechanisms altered by genetic mutations may be important for developing new therapeutic tools, researchers said in the study. Analysis of the serums of 245 participants in two separate studies found increased levels of mitochondrial DNA (mtDNA) and interlebinin 6 (IL-6) circulating in the body of patients with mutations in the Parkin or PINK1 gene.
: Front Frontl: Targeted stem cells can be used to regulate inflammatory responses doi:10.3389/fimmu.2020.585530 periodontology, also known as gum disease, is a serious infectious disease.
if left uncensioned, periodontage can damage the jaw and cause teeth to fall out.
the disease is also associated with a higher risk of diabetes and cardiovascular disease.
current treatment for periodontary disease includes opening infected gum valves and adding bone implants to strengthen teeth.
but in a new study recently published in the journal Frontiers in Immunology, scientists found that a specific type of molecule may stimulate stem cell regeneration, reversing inflammation caused by periodontage disease.
findings could lead to the development of new therapies to treat a variety of systemic diseases characterized by inflammation in the body.
for the study, Dr. Alpdogan Kantarci and his student, Dr. Emmanuel Albuquerque, removed stem cells from previously pulled wisdom teeth and placed them in petri dishes.
, the researchers created a simulated inflammatory periodontological disease environment in a petri dish.
, they added two specific types of synthetic molecules, called Marinen-1 and Resolvin-E1.
have found that Mar1 and RvE1 stimulate stem cell regeneration, even under inflammatory conditions.
( 3) Cell: Researchers at Icahn Medical School in Mount Sinai reported immune characteristics of nine MIS-C cases in a new study that reveals systemic inflammatory and antibody response characteristics in children: 10.1016/j.cell.2020.09.034 In a new study, researchers at the Icahn School of Medicine in Mount Sinai reported immune characteristics.
all MIS-C patients have evidence of previous exposure to SARS-CoV-2, triggering a complete and nalising antibody response.
study was published in the Cell journal.
analysis of cytokines in these MIS-C patients determined elevated characteristics of inflammation (IL-18 and IL-6), lymphocyte and myelin cell activation and activation (CCL3, CCL4, and CDCP1), and mucous membrane immune disorders (IL-17A, CCL20, CCL28).
esotype analysis of external peritonal blood showed a decrease in non-classical monocytes, NK cells, and T lymphocyte sub-groups.
, the researchers dissected the autoantigen reactivity of plasma in MIS-C patients and found known disease-related autoantibodies (anti-La antibodies) and new candidate antibodies that identify endoskin, gastrointestinal and immune cell antigens.
all MIS-C patients were treated with anti-IL6R antibodies and/or IVIG, resulting in rapid remission.
4 (Xinhua) -- Adding SN50 molecules reduces inflammation and improves vaccine protection levels Doi:10.1126/sciadv.aaz8700 adulations are a key ingredient in many modern vaccines that trigger an immune response to help protect the body from disease.
scientists believe adulents are key to developing new vaccines against viruses that are difficult to eradicate, such as HIV.
but advents can cause inflammation at the injection site, as well as side effects of overstulging the immune system, which prevents many promising new candidate advents from being integrated into the vaccine.
a new study, researchers from the University of Chicago's Pritzker School of Molecular Engineering have discovered a new way to limit inflammation caused by adulations: by adding a molecule to disrupt certain pathways in cells.
this molecule not only reduces inflammatory susceptibleness, but also appears to have an additional benefit: an increased protective response to viruses such as influenza, dengue and even HIV.
could eventually be used to develop a vaccine against SARS-CoV-2--- the coronavirus --- that causes COVID-19, the findings were recently published in the journal Science Advances.
researchers say this could lead to the development of a new way to design vaccines.
it goes against the traditional view that increasing inflammation is necessary and that doing so provides more protection.
it's more beneficial than we'd like it to be.
for more than a year, scientists have been exploring the use of Tol-like-like persexual (TLR) agonists as a adrenasts because they activate inflammatory cytokines to make vaccines work.
agonist called CpG DNA has been shown to be a adrenast, and it has even been shown to prevent HIV infection.
but TLR agonists like CpG DNA can induce excessive inflammatory reactions in the body, making it difficult to use in vaccine development.
--Nat Immunol: Neuron-related proteins help relieve inflammation doi:10.1038 /s41590-020-0753-y In a recent study, researchers at Rutgers University may have found keys to treating inflammation, such as asthma, allergies, chronic fibrosis and chronic obstructive pulmonary disease (COPD).
study, published in the journal Nature Immunology, researchers found that neuron B (NMB) is a protein produced by the nervous system that prevents overactive immune responses and disrupts inflammation.
is the body's ability to identify and defend against harmful substances.
helps clear infections, if there are no proper restrictions, the immune response can also promote damaging inflammation.
found that NMB proteins can prevent inflammation in diseases such as asthma, allergies, chronic fibrosis and COPD.
researchers say the mechanism by which the body shuts down its inflammatory response to self-healing after a worm infection has remained little known for years.
our research offers hope for treatment with NMB, which has great potential to treat inflammatory diseases such as asthma, allergies and COPD.
Photo Source: University of Luxembourg 6 PNAS: Key doi:10.1073/pnas.1915950117 Although macrophages play an important role in activating the immune response and addressing tissue inflammation, there is growing evidence that they are associated with a variety of disease processes, such as chronic inflammatory diseases, tumor growth and metastasis, and tissue fibrosis.
Boston University School of Medicine (BUSM) for the first time have masted the origin, gene expression and function of macrophages in normal skeletal muscles.
they believe the findings will provide the basis for future studies of the role of skeletal muscle residering macrophages in skeletal muscle diseases, such as muscular dystrophy, and muscle damage.
people often suffer muscle damage as a result of accidents or exercise, while others suffer from congenital or accessive muscle diseases, such as muscular dystrophy, which exhibits significant muscle inflammation.
muscular dystrophy is the most common inherited muscle disease.
can cause severe disability and premature death due to respiratory and heart muscle weakness, and the disease is currently incurable.
: Revealing the molecular pathogenesies of the key molecule HDAC3 that controls both sides of the body's inflammation, doi:10.1038/s41586-020-2576-2 In a study published in the international journal Nature, scientists from the Perelman School of Medicine at the University of Pennsylvania found a group called group protein deacetylase 3 (HDAC3, hiSTONE) Special proteins may act as a coordinator for the body's immune system's response to infection; after studying specially cultured cells and small animal models, the researchers found that HDAC3 may have been directly involved in the production of harmful pathogenic agents and the process of maintaining stability in the body; and that some methods are being tested to protect against cancer and harmful inflammation, such as sepsis, while targeted molecules such as HDAC3 can actually have unintended consequences.
'Our results suggest that HDAC3 may be the key to the body's congenital immune response because of its yin and yang sides, which both induce inflammation and slow it down,' said Mitchell A. Lazar, M.D., M.D.
now that we understand this, we should be more aware of what we need to target when testing drugs and using them to fight potentially deadly inflammation.
inflammation is a highly complex defensive mechanism used by the body's congenital immune system, that is, it is a person's innate thing, not like the rest of the body's immune system obtained from the day after birth; But it also includes changes in blood flow and vascular permeability, as well as the migration of white blood cells; if well regulated, the inflammatory response quickly and accurately locates and eliminates potential hazards, and then the body enters an anti-inflammatory process that helps remove damaged tissue so that the body can begin to heal and repair.
: Cell Host and Microbe: High-fat diet and antibiotic abuse or directly related to inflammation of the body's intestines doi:10.1016/j.chom.2020.06.001 intestinal irritable syndrome (IBS, Irritable bowel syndrome, affects the health of about 11% of the population worldwide, characterized by recurrent abdominal pain, bloating and changes in bowel habits, inflammation of the mucous membranes and changes in the composition of gut microorganisms in IBS patients are often thought to occur in precursor inflammatory bowel disease (IBD).
, scientists from the University of California and other institutions said a high-fat diet using antibiotics may be directly related to inflammation of the gut in a recent study published in the international journal Cell Host and Microbe. In the
article, researchers studied 43 healthy adults and 49 adult IBS patients who measured levels of calprotectin, a biomarker that indicates inflammation of the intestines, and elevated levels of fecal calcium mesh protein, which indicates symptoms of pre-IBD, and found that 19 IBS patients had pre-IBD symptoms. Participants on a high-fat diet and antibiotic-free diets were 8.6 times more likely to develop pre-IBD than those on a low-fat diet and no history of antibiotic use, while participants who ate the highest fat were 2.8 times more likely to develop pre-IBD than those on a low-fat diet and those with a recent history of antibiotic use were 3.9 times more likely to develop pre-IBD, it was noted.
: The three-dimensional shape of the human genome is critical to the inflammatory response doi:10.1038/s41588-020-0643-0 According to a recent study published in the journal Nature Genetics, the three-dimensional structure of the human genome is critical to providing a rapid and powerful inflammatory response, but surprisingly, not to reprogram one cell type to another.
findings reveal a fundamental relationship between genome folding and cellular function.
each human cell has a genome two meters long and is compressed into 10 microns in the nuclei of the cell.
folding genome is not only a packaging solution, it also helps genes to physically come into contact with other genes or regulatory elements located fairly far from chromosomes.
is critical to cell function.
three-dimensional structure of the genome is woven together by structural proteins.
CTCF is the most important of these structural proteins.
Overall, it helps to form the overall three-dimensional structure of the genome, which is why CTCF has proven to be essential in embryonic development, DNA repair and cell cycles, as well as many other important processes, making it an intensive area of research.
10: Immuno Natl: Scientists identified a special protein, doi:10.1038/s4159, that controls inflammation in the body