"Heart-brained"? The Allen Institute found that when the heart beats, the brain shakes, revealing for the first time how to achieve a scale span in the human brain.

The brain shakes as the heart beats, and researchers use this movement to better understand different types of neurons.in a study published on March 11 in cell reports, a journal of cell press cell publishing house, researchers found that by analyzing the waveform changes of neurons during a heartbeat, different types of neurons in the human brain can be classified more accurately.this study will help us better understand how different types of cells in the brain interact to produce cognition and behavior.Clayton Mosher, CO first author of the paper from cedars Sinai Medical Center, and Yina from Allen Institute "We recorded neurons from patients who had implanted electrodes for neurosurgery, and compared neural activity to heart rate, and found that many neurons changed their firing patterns every time a heartbeat occurred," Wei said.our reaction at the time was' OK, it's amazing.'".with each heartbeat, the brain beats once, and neurons slightly change their position in the brain.the researchers found that neurons moved about 3 microns per heartbeat, narrower than a hair.it is this movement that causes the seemingly different firing patterns of neurons.Costas Anastasiou, one of the co authors of the paper, said: "our starting point - a lot of people think it's a brain movement rather than a neural activity, they think it's noise, it's a lack of experimentation.what we can show is that if this naturally occurring brain movement is applied skillfully, we can learn more about the nature of the neurons being recorded.this is because more information can be obtained by measuring the activity of the same neuron at different locations in the brain."according to the Convention, scientists classify neurons based on their waveforms, that is, the characteristic pattern of electrical activity emitted by each neuron when it is in the active state, i.e." spike ".the waveform of each neuron is different.by measuring the width of waveforms, scientists can divide neurons into two categories: narrow waveform neurons and wide waveform neurons.today, subtle brain movements caused by the heartbeat allow scientists to measure waveform shapes more accurately.when the distance between neurons and electrodes changes, the measured waveform also changes.by measuring these changes, the team identified three types of neurons in the human hippocampus: narrow spike (NS), wide spike one (BS1), and wide spike two (BS2).each has different discharge characteristics: BS1 neurons synchronized with gamma waves, BS2 neurons synchronized with theta waves."gamma waves and theta waves are highly related to cognition in the brain.what is known is that memory and learning are closely related to theta concussion, and attention is closely related to gamma injection."anastassiou said."ultimately, in order to understand how the brain works, we need to know which different cells exist in the brain and how these cell types interact to produce cognition and behavior," anastassiou said. "People need to have cross-scale capabilities to say that changes in the micro world lead to behavioral phenomena in the macro world.our study reveals for the first time how scale spanning can be achieved in the human brain."one of the challenges in neuroscience is that there are always differences in the behavior of neurons in the human body and in the state of separation of brain slices.by recording the activity of human brain tissue, researchers can construct a single cell model simulating the biophysical characteristics and morphology of neurons.as a new tool for classifying neurons, the model builds a bridge between in vivo (in vivo) and in vitro (ex vivo) brain slices.computer models of human neurons can be used to understand the signals in the human body implanted with electrodes.Mosher said: "in the end, what we want to know is: first, how different types of neurons in the human brain act on cognition and behavior; second, how heartbeat and respiration in turn affect cognition or behavior."paper link: