Hawthorn acid may inhibit osteoporosis

Liu Mingyao, Professor of life Medicine Research Institute of East China Normal University, found that hawthorn acid has the effect of inhibiting osteoporosis, and studied its molecular mechanism in depth The results have been published online in the latest issue of the Journal of bone and mineral research With the coming of the aging society in China, more and more aging diseases are bothering people's life and health Osteoporosis is one of the most common According to statistics, there are about 90 million people suffering from osteoporosis in China, especially the majority of women, and the number of patients is increasing year by year, which has become the country with the largest number of patients in the world It is estimated that there will be 280 million patients in China by 2020 According to this situation, Liu Mingyao's research group used osteoclast differentiation model to screen a series of compounds, and finally found that hawthorn acid is a more specific small molecule compound for osteoclast differentiation And through the animal model simulation of osteoporosis caused by menopause, it is confirmed that hawthorn acid can also inhibit osteoclast differentiation and osteoporosis in vivo At the same time, the research group also explored the molecular mechanism of hawthorn acid inhibiting osteoclast differentiation Through immunohistochemistry, immunofluorescence and other experimental techniques, the research team found that hawthorn acid can inhibit the upstream signal of osteoclast differentiation, so as to inhibit osteoclast differentiation Further studies confirmed that hawthorn acid inhibited the activity of NF kappaB, a downstream signal of the binding, and the expression of NFATc1, but had no effect on the transcription activity of NFATc1 In addition, hawthorn acid can also regulate the activity of another downstream signal MAPK, but has no obvious effect on calcium flow oscillation These results are consistent with each other, indicating that the key inhibition target of hawthorn acid on osteoclast differentiation lies in the upstream signal Therefore, through the research of animal, cell and molecular mechanism, the research team proved that hawthorn acid may be a new drug to prevent osteoporosis caused by menopause Under the guidance of Liu Mingyao and Luo Jian, associate professor, Li Chenghai, graduate student of the Institute of life medicine of East China Normal University, etc., cooperated with Tang Jie, Professor of Chemistry Department of East China Normal University, and Qiu Wenwei, associate professor It is reported that in view of China's national conditions, on the one hand, the research group has studied the causes of osteoporosis and bone development from the molecular mechanism, on the other hand, it has set up the osteoporosis drug screening platform, which is dedicated to screening and developing safe and effective osteoporosis drugs At present, many kinds of Chinese herbal monomers and their derivatives have been found to have anti osteoporosis activity, and many research papers have been published.