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▎The content team editor of WuXi AppTec.
Diabetes is a common chronic disease that affects more than 400 million people worldwide.
It is estimated that this number will increase to more than 600 million by 2045.
China is a veritable big country with diabetes.
The 2020 edition of the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China" shows that the prevalence of diabetes in China is as high as 11.
2%, which has become the second largest chronic disease after hypertension.
In many people's minds, although type 2 diabetes is common, it is not painful or itchy, and even if it is harmful, it will not cause serious consequences.
But in fact, type 2 diabetes can not only cause serious complications such as ketoacidosis, hyperglycemia and hyperosmolality, nephropathy, retinopathy, neuropathy, and diabetic foot; more and more studies have found that type 2 diabetes is also related to Cancer, a terrible disease, is associated with "entanglement".
Recently, a study published in the Journal of the National Cancer Institute added evidence for the association between type 2 diabetes and cancer.
Studies have shown that type 2 diabetes is associated with an increased risk of a variety of cancers, especially in the 6-8 years after suffering from type 2 diabetes, the overall cancer risk has increased by nearly 40%.
Image source: 123RF comes from Harvard TH Chan School of Public Health and other institutions.
Researchers conducted a follow-up analysis of 159,033 subjects aged 30-75 years old in the United States, 71% of them were women.
Through the questionnaire, the researchers counted the subjects’ basic health indicators, family history of cancer and type 2 diabetes, life>
In addition, the researchers also collected the incidence of cancer and type 2 diabetes during the study period; and followed up the subjects every two years to update the information.
During the average follow-up period of 30 years, 43,849 cases of cancer occurred.
Image source: After 123RF adjusted for other factors, researchers found that type 2 diabetes was associated with a higher risk of cancer.
Compared with subjects without type 2 diabetes, having type 2 diabetes is associated with a 21% increase in overall cancer risk.
In terms of specific cancer types, type 2 diabetes is associated with an increased risk of more than 10 cancers, including a 21% increase in the risk of colorectal cancer, a 27% increase in the risk of lung cancer, a 107% increase in the risk of pancreatic cancer, and an increase in the risk of esophageal cancer.
85%, 18% increased risk of kidney cancer, 239% increased risk of liver cancer, 49% increased risk of thyroid cancer, 33% increased risk of gallbladder cancer, 26% increased risk of breast cancer, and increased risk of endometrial cancer26 %.
At the same time, the study also found that when the course of type 2 diabetes is 6-8, the increase in cancer risk reaches its peak.
Compared with subjects without type 2 diabetes, the duration of diabetes was 2.
1-4 years, 4.
1-6 years, 6.
1-8 years, 8.
1-10 years, 10.
1-15 years, and more than 15 years, respectively, compared with the overall cancer 13%, 28%, 37%, 21%, 16%, and 4% increase in risk are related.
In different cancer types, researchers have also found similar trends.
Researchers analyzed that type 2 diabetes may increase the risk of cancer through various mechanisms such as insulin resistance, hyperinsulinemia, abnormal blood sugar control, and inflammation.
However, the relevant biological mechanisms are not yet fully understood, and further research and exploration are still needed.
Image source: 123RF As the study is an observational study, it only shows the association between type 2 diabetes and the overall risk of cancer and increased risk of multiple types of cancer, and does not indicate a causal relationship.
There are also limitations to the study, such as part of the data relied on the recall of subjects; after the diagnosis of type 2 diabetes, changes in the life>
The study finally emphasized that more and more evidence shows that there is a close link between type 2 diabetes and cancer risk.
Type 2 diabetes may be a direct risk factor for cancer.
In order to prevent the occurrence of cancer, type 2 diabetes should be prevented.
Researchers pointed out that type 2 diabetes and cancer have some common risk factors, such as excess weight, unhealthy diet, smoking, drinking, and lack of exercise.
Management of these changeable risk factors, healthy living, enhanced screening and drug treatment, etc.
, will help to better reduce the risk of cancer and type 2 diabetes.
Weight control: Maintain a healthy weight.
If you are overweight, obese or central obesity (waist circumference ≥90 cm for men, waist circumference ≥85 cm for women), you can reduce weight through diet or exercise.
Relevant data show that the prevalence of type 2 diabetes in obese and overweight people has increased significantly, and the prevalence of type 2 diabetes in obese people has increased by a factor of two.
The incidence of type 2 diabetes in people with body mass index (BMI) <25 was 7.
8%, the incidence of people with 25≤BMI <30 was 15.
4%, and the incidence of people with BMI≥30 was 21.
2%.
Image source: 123RF reasonable diet: healthy diet, choose foods with low fat and calorie content and high fiber content; increase the intake of fruits, vegetables and whole grains, and reduce the intake of sugar and salt.
Quit smoking: A study conducted by researchers from the International Agency for Research on Cancer (IARC) and the European Prospective Survey of Cancer and Nutrition (EPIC) found that compared with non-smokers, smokers have an increased risk of type 2 diabetes by 35 %.
Strengthen exercise: At least 150 minutes of moderate-intensity exercise or 75 minutes of high-intensity physical activity every week.
Avoid sedentary behavior: sitting for a long time will increase the risk of illness.
Try to get up and move for a few minutes after sitting for 30 minutes. Diabetes screening: For people at high risk of type 2 diabetes, such as age ≥ 40 years, impaired glucose tolerance, high blood pressure, dyslipidemia, overweight, obesity or central obesity, sedentary life>
For people whose first screening results are normal, the screening should be repeated at least once every 3 years.
For diabetic patients, while adhering to medications and other treatments, they should maintain a healthy life>
It is recommended to read a glass of milk a day.
Is it harmful to drink? | If you need a reason to quit smoking on World Milk Day, is more than 100 enough? ! How can World No Tobacco Day extend life? Studies have found that joint pain associated with more walking and a lower risk of death is gout? These types of arthritis may also be "causing" Harvard Medical School Research to reduce heart damage and heart failure, the daily diet should be eaten like this Reference materials [1] Yang Hu, et al.
, (2021).
Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial.
Journal of the National Cancer Institute, DOI: https://doi.
org/10.
1093/jnci/djaa141.
[2] Chinese Medical Association Diabetes Branch .
China Type 2 Diabetes Prevention and Control Guidelines (2020 edition).
[3] Ge Junbo, Xu Yongjian, Wang Chen.
Internal Medicine [M].
9th edition.
Beijing: People's Medical Publishing House, 2018.
Note: This article aims to introduce medical and health research.
Progress is not a recommended treatment plan.
If you need guidance on the treatment plan, please go to a regular hospital for treatment.
Diabetes is a common chronic disease that affects more than 400 million people worldwide.
It is estimated that this number will increase to more than 600 million by 2045.
China is a veritable big country with diabetes.
The 2020 edition of the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China" shows that the prevalence of diabetes in China is as high as 11.
2%, which has become the second largest chronic disease after hypertension.
In many people's minds, although type 2 diabetes is common, it is not painful or itchy, and even if it is harmful, it will not cause serious consequences.
But in fact, type 2 diabetes can not only cause serious complications such as ketoacidosis, hyperglycemia and hyperosmolality, nephropathy, retinopathy, neuropathy, and diabetic foot; more and more studies have found that type 2 diabetes is also related to Cancer, a terrible disease, is associated with "entanglement".
Recently, a study published in the Journal of the National Cancer Institute added evidence for the association between type 2 diabetes and cancer.
Studies have shown that type 2 diabetes is associated with an increased risk of a variety of cancers, especially in the 6-8 years after suffering from type 2 diabetes, the overall cancer risk has increased by nearly 40%.
Image source: 123RF comes from Harvard TH Chan School of Public Health and other institutions.
Researchers conducted a follow-up analysis of 159,033 subjects aged 30-75 years old in the United States, 71% of them were women.
Through the questionnaire, the researchers counted the subjects’ basic health indicators, family history of cancer and type 2 diabetes, life>
In addition, the researchers also collected the incidence of cancer and type 2 diabetes during the study period; and followed up the subjects every two years to update the information.
During the average follow-up period of 30 years, 43,849 cases of cancer occurred.
Image source: After 123RF adjusted for other factors, researchers found that type 2 diabetes was associated with a higher risk of cancer.
Compared with subjects without type 2 diabetes, having type 2 diabetes is associated with a 21% increase in overall cancer risk.
In terms of specific cancer types, type 2 diabetes is associated with an increased risk of more than 10 cancers, including a 21% increase in the risk of colorectal cancer, a 27% increase in the risk of lung cancer, a 107% increase in the risk of pancreatic cancer, and an increase in the risk of esophageal cancer.
85%, 18% increased risk of kidney cancer, 239% increased risk of liver cancer, 49% increased risk of thyroid cancer, 33% increased risk of gallbladder cancer, 26% increased risk of breast cancer, and increased risk of endometrial cancer26 %.
At the same time, the study also found that when the course of type 2 diabetes is 6-8, the increase in cancer risk reaches its peak.
Compared with subjects without type 2 diabetes, the duration of diabetes was 2.
1-4 years, 4.
1-6 years, 6.
1-8 years, 8.
1-10 years, 10.
1-15 years, and more than 15 years, respectively, compared with the overall cancer 13%, 28%, 37%, 21%, 16%, and 4% increase in risk are related.
In different cancer types, researchers have also found similar trends.
Researchers analyzed that type 2 diabetes may increase the risk of cancer through various mechanisms such as insulin resistance, hyperinsulinemia, abnormal blood sugar control, and inflammation.
However, the relevant biological mechanisms are not yet fully understood, and further research and exploration are still needed.
Image source: 123RF As the study is an observational study, it only shows the association between type 2 diabetes and the overall risk of cancer and increased risk of multiple types of cancer, and does not indicate a causal relationship.
There are also limitations to the study, such as part of the data relied on the recall of subjects; after the diagnosis of type 2 diabetes, changes in the life>
The study finally emphasized that more and more evidence shows that there is a close link between type 2 diabetes and cancer risk.
Type 2 diabetes may be a direct risk factor for cancer.
In order to prevent the occurrence of cancer, type 2 diabetes should be prevented.
Researchers pointed out that type 2 diabetes and cancer have some common risk factors, such as excess weight, unhealthy diet, smoking, drinking, and lack of exercise.
Management of these changeable risk factors, healthy living, enhanced screening and drug treatment, etc.
, will help to better reduce the risk of cancer and type 2 diabetes.
Weight control: Maintain a healthy weight.
If you are overweight, obese or central obesity (waist circumference ≥90 cm for men, waist circumference ≥85 cm for women), you can reduce weight through diet or exercise.
Relevant data show that the prevalence of type 2 diabetes in obese and overweight people has increased significantly, and the prevalence of type 2 diabetes in obese people has increased by a factor of two.
The incidence of type 2 diabetes in people with body mass index (BMI) <25 was 7.
8%, the incidence of people with 25≤BMI <30 was 15.
4%, and the incidence of people with BMI≥30 was 21.
2%.
Image source: 123RF reasonable diet: healthy diet, choose foods with low fat and calorie content and high fiber content; increase the intake of fruits, vegetables and whole grains, and reduce the intake of sugar and salt.
Quit smoking: A study conducted by researchers from the International Agency for Research on Cancer (IARC) and the European Prospective Survey of Cancer and Nutrition (EPIC) found that compared with non-smokers, smokers have an increased risk of type 2 diabetes by 35 %.
Strengthen exercise: At least 150 minutes of moderate-intensity exercise or 75 minutes of high-intensity physical activity every week.
Avoid sedentary behavior: sitting for a long time will increase the risk of illness.
Try to get up and move for a few minutes after sitting for 30 minutes. Diabetes screening: For people at high risk of type 2 diabetes, such as age ≥ 40 years, impaired glucose tolerance, high blood pressure, dyslipidemia, overweight, obesity or central obesity, sedentary life>
For people whose first screening results are normal, the screening should be repeated at least once every 3 years.
For diabetic patients, while adhering to medications and other treatments, they should maintain a healthy life>
It is recommended to read a glass of milk a day.
Is it harmful to drink? | If you need a reason to quit smoking on World Milk Day, is more than 100 enough? ! How can World No Tobacco Day extend life? Studies have found that joint pain associated with more walking and a lower risk of death is gout? These types of arthritis may also be "causing" Harvard Medical School Research to reduce heart damage and heart failure, the daily diet should be eaten like this Reference materials [1] Yang Hu, et al.
, (2021).
Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial.
Journal of the National Cancer Institute, DOI: https://doi.
org/10.
1093/jnci/djaa141.
[2] Chinese Medical Association Diabetes Branch .
China Type 2 Diabetes Prevention and Control Guidelines (2020 edition).
[3] Ge Junbo, Xu Yongjian, Wang Chen.
Internal Medicine [M].
9th edition.
Beijing: People's Medical Publishing House, 2018.
Note: This article aims to introduce medical and health research.
Progress is not a recommended treatment plan.
If you need guidance on the treatment plan, please go to a regular hospital for treatment.
