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Visualizing cell behavior and effector functions at the individual cell level is essential for understanding key aspects of mammalian biology
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Because of their small size, high number, and rapid recruitment into thrombi , there is a lack of data on the fate and behavior of individual platelets in thrombosis and hemostasis
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Visualizing cell behavior and effector functions at the individual cell level is essential for understanding key aspects of mammalian biology
Recently, foreign scholars reported the use of multicolor reporter mouse strains with limited platelet lineage to depict platelet function at the single-cell level
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Recently, foreign scholars reported the use of multicolor reporter mouse strains with limited platelet lineage to depict platelet function at the single-cell level
Using Creative Confetti expression, they provided insights into temporal gene expression patterns and spatial clustering of megakaryocytes in the bone marrow
Combined with flow cytometry and in vivo , in vitro, and in vitro platelet function determination imaging showed that compared with WT control, the platelet function of multicolor reporter mice was unchanged
Original source:
Original source:Nicolai L, Kaiser R, Escaig R, Hoffknecht ML, Anjum A, Leunig A, Pircher J, Ehrlich A, Lorenz M, Ishikawa-Ankerhold H, Aird WC, Massberg S, Gaertner F.
Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivoNicolai L, Kaiser R, Escaig R, Hoffknecht ML, Anjum A, Leunig A, Pircher J, Ehrlich A, Lorenz M, Ishikawa-Ankerhold H, Aird WC, Massberg S, Gaertner F.
Single platelet and megakaryocyte morpho-dynamics uncovered by Reporter Mouse strains Multicolor in vitro and in Vivo in vitro in Vivo in this message
