GWAS application in Arabidopsis
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Last Update: 2010-06-04
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Source: Internet
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Author: User
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Large scale genome-wide association research (GWAS) has become an important tool in human genomics The focus of GWAS is mostly disease, but also adaptive variation such as skin color Now, this method has been found to be equally useful in plants Atwell et al Reported a GWA study of more than 100 genotypes in naturally occurring inbred Arabidopsis Their results range from "significantly correlated" (usually for a single gene) to "more difficult to decipher," suggesting that complex genetic factors and population structure interact Another accompanying paper published by todesco et al Shows the ability of this method to detect "major influence" gene loci Using forward genetics and GWA analysis, they found that the variation at a single locus (acd6) in Arabidopsis was responsible for the phenotypic variation in plant growth and resistance to infection The significant increase in resistance regulated by one of the alleles at this site may explain why it persists in natural populations around the world, although this significantly reduces the generation of new leaves.
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