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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Daisy Guide: The King of Cancer-Why is Pancreatic Cancer So Difficult to Treat? The gut microbiome may play a role in the occurrence and progression of pancreatic cancer
.
On November 24, a study published in "Gut Microbes" showed that the researchers analyzed the live bacteria in pancreatic cystic lesions for the first time.
These bacteria are precursors of pancreatic cancer and can be intervened by antibiotics
.
Researchers found that the presence of oral bacteria in the pancreas may be a measure of the severity of IPMN lesions
.
By capturing live pancreatic bacteria, Gammaproteobacteria and Bacilli bacteria were found to be dominant
.
These bacteria are usually found in the digestive tract and can metabolize cancer drugs, driving immunosuppression and tumorigenesis
.
They infect pancreatic cells and even hide in pancreatic cells, causing double-stranded DNA breaks to induce cell damage
.
Pancreatic cancer is one of the common malignant tumors of the digestive tract, and is known as the "king of cancer" in the field of tumors
.
According to The Lancet, the five-year survival rate after diagnosis of pancreatic cancer is about 10%, which is one of the worst-prognostic malignant tumors
.
Studies have found that bacteria from the digestive system seem to cause damage to pancreatic cells and increase the risk of malignant tumors
.
Now, researchers from the Karolinska Institute in Sweden have analyzed the live bacteria in pancreatic cystic lesions for the first time, which are precursors of pancreatic cancer
.
The study, published in the journal Gut Microbes on November 24, can use antibiotics for preventive intervention
.
Researchers published an article entitled "Isolation of pancreatic microbiota from cystic precursors of pancreatic cancer with intracellular growth and DNA damaging properties": https:// Pancreas Carcinoma (PC) is one of the most aggressive and deadly cancers
.
The 5-year survival rate at diagnosis is about 10%, because about 80-85% of patients have unresectable or metastatic disease
.
And it may have vague symptoms in the early stage, if any, it is usually found late, by then it has spread
.
Therefore, at the time of diagnosis, most of the patients' disease is already in an advanced stage
.
According to GLOBOCAN's 2018 estimates, PC accounted for approximately 459,000 new cases and 432,000 deaths
.
Emerging global data indicate that PC diagnosis and mortality have increased by two to three times, especially in countries with high sociodemographic indexes
.
It now appears that pancreatic cancer will soon surpass breast cancer as the third most common cause of cancer-related deaths in the European Union
.
Cystic lesions of the pancreas, including intraductal papillary mucinous tumors (IPMNs) are common
.
Because they are considered to be precursors of pancreatic cancer, many patients require regular lifelong check-ups, and a small number of patients also require surgery
.
Understanding the risk factors of cancer is valuable to individuals and medical institutions
.
Reducing the effects of cytostatics The link between IPMNs and pancreatic cancer is not fully understood, but early studies at the Karolinska Institute and elsewhere have shown that the presence of oral bacteria in the pancreas may be a measure of the severity of IPMN lesions Indicators
.
The Karolinska Institute researchers have now built on the results of their previous research
.
By using modern culture methods and a new proteomics technology, they have been able to capture live pancreatic bacteria for research in the laboratory
.
In this new study, they analyzed the cystic fluid of 29 patients undergoing pancreatic cystic tumor surgery between 2018 and 2019
.
Their results showed that the ratio of Gammaproteobacteria and another type of bacteria called Bacilli was too high
.
Reports that have appeared in recent years indicate that the pancreas is an organ previously considered sterile and seems to contain a unique microbiome
.
Recent studies in experimental animal models have further shown that bacteria from the pancreatic microbiome can metabolize cancer drugs, reduce the efficiency of cancer chemotherapy, and drive immunosuppression and tumorigenesis
.
These bacteria are usually found in the digestive tract, and previous studies have shown that it promotes cancer resistance by interfering with the action of gemcitabine, a cytostatic drug used in the treatment of pancreatic cancer
.
Studies have shown that these bacteria are present in IPMNs and can be cultured in 24% of cases
.
In the further study of the first stage disease in the laboratory, the researchers found that many of these bacteria may infect pancreatic cells or even hide in pancreatic cells, causing harmful consequences
.
Professor Margaret Sällberg Chen of the Department of Dental Medicine at the Karolinska Institute explained: “Some bacteria may cause double-stranded DNA breaks, which are considered the first step in cell pathology and cancer
.
We also found that antibiotics can prevent DNA damage
.
We The discovery not only confirmed that bacteria play an important role in the development of cancer, but also shed light on new ways to attack this process
.
"Healthy (hTERT-HPNE), early stage (Capan-2) and advanced differentiated cancer (AsPC-1) ) DNA damage caused by bacterial isolates in pancreatic cell lines.
The question of how digestive tract bacteria enter the pancreas and then hide in pancreatic cells remains to be answered
.
Volkan Özenci, senior consultant and associate professor of the Department of Laboratory Medicine at the Karolinska Institute, said: “Under normal circumstances, the duct from the intestines to the pancreas is closed, but if there is inflammation or injury, bacteria may slip in
.
Bacteria .
It is likely that they migrated from the oral cavity and gastrointestinal tract to the pancreas through this pipeline
.
Some bacteria can also hide in human cells, such as white blood cells, and use these cells to enter the pancreas
.
"The team said that their findings have clinical potential.
Application value
.
Obviously, these recent insights emphasize the importance of microbiome analysis as an alternative method to further improve the clinical diagnosis and treatment of pancreatic diseases
.
Dr.
Asif Halimi, a surgeon and doctoral student in the Department of Clinical Sciences, Intervention and Technology of Karolinska Institutet, one of the study’s first authors, said: “For example, patients with IPMNs can be screened for this type of bacteria.
Check is important
.
We have discussed the possibility of introducing antibiotic therapy, such as combined endoscopy or treatment
.
This will reduce the risk of bacterial infections and prevent future problems
.
"Researchers are now studying whether DNA damage requires physical bacteria or metabolites from bacteria
.
They are also mapping the source of bacteria in the gastrointestinal tract and comparing them with those found in the oral cavity
.
Reference: https://medicalxpress.
com/news/2021-11-bacteria-pancreatic-cancer.
html Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity [Live] Full Clinical Application and Progress of Exome Sequencing (WES) in Genetic Diseases Practitioners-Single Cell Research Creation Camp (Guangzhou Station) Popular·Articles Tumor Research [eLife] Benign moles become malignant melanomas, the middle What happened? Gut microbes [BMJ sub-Journal] Why are good foods suddenly intolerant? New research has identified a unique spectrum of gut bacteria that are highly sensitive to dietary therapy for irritable bowel syndrome, the new coronavirus [Nature sub-Journal] Humans From the perspective of genetics-how genetic mutations affect our immune cells and cause different severity of COVID-19.
New coronavirus [Nature Sub-Journal] Appropriate vitamin D supplementation can fight inflammation, including New Coronary Pneumonia! Cancer Research [Cell Sub-Journal] Massachusetts Researchers from Polytechnic have discovered a secret way to fight tumors-wear tumor cell vests and kill tumor cells! Basic research [Nature sub-Journal] Amazing! 3D images of mouse skulls help scientists create new bones! Basic research 【ATS Sub-Journal】Breakthrough! To draw the most comprehensive map of the molecular route of human lung proteins, scientists have identified and measured 8,938 proteins!
Please indicate the source for reprinting.
Author: Daisy Guide: The King of Cancer-Why is Pancreatic Cancer So Difficult to Treat? The gut microbiome may play a role in the occurrence and progression of pancreatic cancer
.
On November 24, a study published in "Gut Microbes" showed that the researchers analyzed the live bacteria in pancreatic cystic lesions for the first time.
These bacteria are precursors of pancreatic cancer and can be intervened by antibiotics
.
Researchers found that the presence of oral bacteria in the pancreas may be a measure of the severity of IPMN lesions
.
By capturing live pancreatic bacteria, Gammaproteobacteria and Bacilli bacteria were found to be dominant
.
These bacteria are usually found in the digestive tract and can metabolize cancer drugs, driving immunosuppression and tumorigenesis
.
They infect pancreatic cells and even hide in pancreatic cells, causing double-stranded DNA breaks to induce cell damage
.
Pancreatic cancer is one of the common malignant tumors of the digestive tract, and is known as the "king of cancer" in the field of tumors
.
According to The Lancet, the five-year survival rate after diagnosis of pancreatic cancer is about 10%, which is one of the worst-prognostic malignant tumors
.
Studies have found that bacteria from the digestive system seem to cause damage to pancreatic cells and increase the risk of malignant tumors
.
Now, researchers from the Karolinska Institute in Sweden have analyzed the live bacteria in pancreatic cystic lesions for the first time, which are precursors of pancreatic cancer
.
The study, published in the journal Gut Microbes on November 24, can use antibiotics for preventive intervention
.
Researchers published an article entitled "Isolation of pancreatic microbiota from cystic precursors of pancreatic cancer with intracellular growth and DNA damaging properties": https:// Pancreas Carcinoma (PC) is one of the most aggressive and deadly cancers
.
The 5-year survival rate at diagnosis is about 10%, because about 80-85% of patients have unresectable or metastatic disease
.
And it may have vague symptoms in the early stage, if any, it is usually found late, by then it has spread
.
Therefore, at the time of diagnosis, most of the patients' disease is already in an advanced stage
.
According to GLOBOCAN's 2018 estimates, PC accounted for approximately 459,000 new cases and 432,000 deaths
.
Emerging global data indicate that PC diagnosis and mortality have increased by two to three times, especially in countries with high sociodemographic indexes
.
It now appears that pancreatic cancer will soon surpass breast cancer as the third most common cause of cancer-related deaths in the European Union
.
Cystic lesions of the pancreas, including intraductal papillary mucinous tumors (IPMNs) are common
.
Because they are considered to be precursors of pancreatic cancer, many patients require regular lifelong check-ups, and a small number of patients also require surgery
.
Understanding the risk factors of cancer is valuable to individuals and medical institutions
.
Reducing the effects of cytostatics The link between IPMNs and pancreatic cancer is not fully understood, but early studies at the Karolinska Institute and elsewhere have shown that the presence of oral bacteria in the pancreas may be a measure of the severity of IPMN lesions Indicators
.
The Karolinska Institute researchers have now built on the results of their previous research
.
By using modern culture methods and a new proteomics technology, they have been able to capture live pancreatic bacteria for research in the laboratory
.
In this new study, they analyzed the cystic fluid of 29 patients undergoing pancreatic cystic tumor surgery between 2018 and 2019
.
Their results showed that the ratio of Gammaproteobacteria and another type of bacteria called Bacilli was too high
.
Reports that have appeared in recent years indicate that the pancreas is an organ previously considered sterile and seems to contain a unique microbiome
.
Recent studies in experimental animal models have further shown that bacteria from the pancreatic microbiome can metabolize cancer drugs, reduce the efficiency of cancer chemotherapy, and drive immunosuppression and tumorigenesis
.
These bacteria are usually found in the digestive tract, and previous studies have shown that it promotes cancer resistance by interfering with the action of gemcitabine, a cytostatic drug used in the treatment of pancreatic cancer
.
Studies have shown that these bacteria are present in IPMNs and can be cultured in 24% of cases
.
In the further study of the first stage disease in the laboratory, the researchers found that many of these bacteria may infect pancreatic cells or even hide in pancreatic cells, causing harmful consequences
.
Professor Margaret Sällberg Chen of the Department of Dental Medicine at the Karolinska Institute explained: “Some bacteria may cause double-stranded DNA breaks, which are considered the first step in cell pathology and cancer
.
We also found that antibiotics can prevent DNA damage
.
We The discovery not only confirmed that bacteria play an important role in the development of cancer, but also shed light on new ways to attack this process
.
"Healthy (hTERT-HPNE), early stage (Capan-2) and advanced differentiated cancer (AsPC-1) ) DNA damage caused by bacterial isolates in pancreatic cell lines.
The question of how digestive tract bacteria enter the pancreas and then hide in pancreatic cells remains to be answered
.
Volkan Özenci, senior consultant and associate professor of the Department of Laboratory Medicine at the Karolinska Institute, said: “Under normal circumstances, the duct from the intestines to the pancreas is closed, but if there is inflammation or injury, bacteria may slip in
.
Bacteria .
It is likely that they migrated from the oral cavity and gastrointestinal tract to the pancreas through this pipeline
.
Some bacteria can also hide in human cells, such as white blood cells, and use these cells to enter the pancreas
.
"The team said that their findings have clinical potential.
Application value
.
Obviously, these recent insights emphasize the importance of microbiome analysis as an alternative method to further improve the clinical diagnosis and treatment of pancreatic diseases
.
Dr.
Asif Halimi, a surgeon and doctoral student in the Department of Clinical Sciences, Intervention and Technology of Karolinska Institutet, one of the study’s first authors, said: “For example, patients with IPMNs can be screened for this type of bacteria.
Check is important
.
We have discussed the possibility of introducing antibiotic therapy, such as combined endoscopy or treatment
.
This will reduce the risk of bacterial infections and prevent future problems
.
"Researchers are now studying whether DNA damage requires physical bacteria or metabolites from bacteria
.
They are also mapping the source of bacteria in the gastrointestinal tract and comparing them with those found in the oral cavity
.
Reference: https://medicalxpress.
com/news/2021-11-bacteria-pancreatic-cancer.
html Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance, please go to a regular hospital
.
Recommendation·Activity [Live] Full Clinical Application and Progress of Exome Sequencing (WES) in Genetic Diseases Practitioners-Single Cell Research Creation Camp (Guangzhou Station) Popular·Articles Tumor Research [eLife] Benign moles become malignant melanomas, the middle What happened? Gut microbes [BMJ sub-Journal] Why are good foods suddenly intolerant? New research has identified a unique spectrum of gut bacteria that are highly sensitive to dietary therapy for irritable bowel syndrome, the new coronavirus [Nature sub-Journal] Humans From the perspective of genetics-how genetic mutations affect our immune cells and cause different severity of COVID-19.
New coronavirus [Nature Sub-Journal] Appropriate vitamin D supplementation can fight inflammation, including New Coronary Pneumonia! Cancer Research [Cell Sub-Journal] Massachusetts Researchers from Polytechnic have discovered a secret way to fight tumors-wear tumor cell vests and kill tumor cells! Basic research [Nature sub-Journal] Amazing! 3D images of mouse skulls help scientists create new bones! Basic research 【ATS Sub-Journal】Breakthrough! To draw the most comprehensive map of the molecular route of human lung proteins, scientists have identified and measured 8,938 proteins!
