Gut: Ma Yanlei's team from Fudan University reveals the characteristics of intestinal flora, metabolites and bacterial enzymes in young colorectal cancer

Recently, Professor Ma Yanlei's team from Fudan University Affiliated Cancer Hospital published a research paper titled: Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer in GUT journa.

The study revealed for the first time that the onset age of young bowel cancer (early-onset bowel cancer) and elderly bowel cancer older than 50 years of age (late-onset bowel cancer) were significantly different in gut microbiota, metabolic profile, bacterial enzymes There are significant differences in gene spectrum changes, et.

This exploratory research work provides a new perspective and direction for understanding the pathogenesis of intestinal cancer in young people and for exploring early screening and early diagnosis of intestinal cancer suitable for young peopl.

Bowel cancer shows a trend of younger people, and young people lack effective early screening "sharp tools"

Colorectal cancer is one of the most common digestive tract malignancies and is generally considered a disease of the elderl.

It is reported that community colorectal cancer screening was first included in the Shanghai public health service project in 2013, mainly targeting the elderl.

"Although colonoscopy is an effective tool for detecting colon cancer, the benefits of using colonoscopy for early screening in young people may not outweigh the risks, and overdiagnosis may cause unnecessary economic burde.

At present, exploring and developing better risk prediction tools to assist in the early identification of such high-risk young patients with colorectal cancer and establishing better screening strategies have become the focus of current clinical research on colorectal cancer in young adult.

Mapping the microbiota and metabolite profiles of intestinal cancer in young people to reveal the strategies and directions for early screening and diagnosis in the future

The gut microbiota is an important microenvironment related to the health of the human gu.

Are there pathogenic bacteria and metabolite profiles with diagnostic value in young patients with colorectal cancer?

Are these microbiota and metabolites important pathogenic factors in the development of intestinal cancer in young adults?

In response to these unresolved problems and questions in the academic community, Professor Ma Yanlei led a team for four years to conduct fecal metagenomic and metabolomics sequencing analysis on a total of 549 cases of Chinese young intestinal cancer, elderly intestinal cancer and age-matched healthy control.

For the first time in the world, the research team mapped the gut microbiota and metabolite profiles of young Chinese colon cancer patients through a large-sample cohor.

The study found that the multi-omics characteristics of young colorectal cancer were mainly characterized by the enrichment of pathogenic bacteria Flavonifractor plautii, the enrichment of red meat diet-related bacteria, and the increase of tryptophan, bile acid and choline metabolism; Activation of reaction pathways composed of alkali metabolites and bacterial choline metabolizing enzymes may be potential intervention targets for the development of intestinal cancer in young adult.

Based on the research results of intestinal flora spectrum and multi-omics characteristics of young people's intestinal cancer, Professor Ma Yanlei put forward the following health tips for young people to prevent intestinal cancer: First of all, high-risk factors should be avoided, such as quitting smoking, avoiding fried foods, and eating as little as possible high cholesterol, High-fat foods, change bad eating habits, increase the intake of dietary fiber and vitamins, appropriately increase physical exercise and maintain a happy moo.

Original source:

Cheng Kong, et a.