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Pancreatic cancer is a kind of cancer with a high fatality rate.
Pancreatic cancer screening
This study aims to evaluate the long-term benefits of pancreatic cancer surveillance in high-risk genetically susceptible populations.
This study aims to evaluate the long-term benefits of pancreatic cancer surveillance in high-risk genetically susceptible populations.
From 2006 to 2019, researchers retrospectively recruited asymptomatic individuals with an estimated lifetime risk of pancreatic ductal adenocarcinoma (PDAC) ≥10%.
In total, 366 individuals were recruited, including 201 non-mutant relatives of familial pancreatic cancer (FPC) patients and 165 PDAC susceptible gene mutation carriers .
A total of 366 individuals were recruited, including 201 non-mutant relatives of familial pancreatic cancer (FPC) patients and 165 PDAC susceptible gene mutation carriers
Cumulative incidence of pancreatic cancer
Cumulative incidence of pancreatic cancerTen individuals suffered from PDAC, four of whom were symptomatic septal carcinoma, and six were successfully surgically removed.
The cumulative incidence of PDAC in mutation carriers is 9.
Sensitivity to detect pancreatic lesions
Sensitivity to detect pancreatic lesions17 (4.
17 (4.
In summary, for known carriers of high-risk mutations, regular follow-up PDAC diagnosis rate is relatively high, but no PDAC was found in FPC relatives who do not carry the mutation.
The diagnostic effect produced by imaging means is not good.
Original source:
Overbeek KA, Levink IJM, Koopmann BDM, et al Long-term yield of pancreatic cancer surveillance in high-risk individuals Gut Published Online First: 05 April 2021.
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