Growth factors: human adaptive immunity depends on the factors of leukocyte formation

February 13, 2020 news / bio grain / -- granulocyte colony stimulating factor (G-CSF) can cause the division and differentiation of bone marrow cells according to the needs of the body for white blood cells, which not only has a significant regulatory effect on innate immunity, but also has a significant regulatory effect on adaptive immunity This is the latest discovery by scientists from ikbfu and the Institute of basic and clinical immunology Scientists published an article on the study in the journal growth factors G-CSF plays a key role in the formation of granulocytes in bone marrow, which is the site with the largest number of leukocytes This is one of the most important immune processes, because leukocytes are the basis of anti infection protection G-CSF can be produced by bone marrow cells, blood vessels, connective tissue and astrocytes that play a structural role in the nervous system In addition, depending on the situation, the human body can produce different amounts of G-CSF This factor acts on bone marrow stem cells and myeloid cells and binds to a special receptor protein (CD114) on their surface This combination enhances cell growth and stimulates cell transformation to granulocytes, which have a strong non-specific ability to capture and digest viruses and bacteria Photo source: https://cn.bing.com the author of this study, supported by the federal committee of the Ministry of science and education, proposed that G-CSF may be an important tool for regulating the long-term adaptation of immunity to various environmental conditions To test this, scientists collected venous blood from 16 healthy men and women between the ages of 21 and 40 Macrophages responsible for adaptive immune response were isolated from their blood The authors then studied the effect of G-CSF on these cells The results showed that IL-6 had the most significant stimulating effect on the production of macrophages secreting IL-6 IL-6 was a cytokine involved in the adaptation of various tissues to the environment In addition, G-CSF can also reduce the number of IFN receptor on macrophages, and inhibit the development of tissue damaging inflammation Based on these data, it can be concluded that G-CSF not only continuously regulates adaptive immunity, but also participates in the recovery process Viktor seledtsov, chief scientist of ikbfu Medical Biotechnology Center, commented on the results: "now G-CSF is mainly used for the treatment of leukopenia, which means that the number of white blood cells is insufficient However, in the future, it can be used not only to correct adaptive inflammation, but also to stimulate the regeneration of damaged tissues "Reference: v I seledtsov et al, granulocyte colony-stimulating factor downward regulated interaction gamma receiver expression and stimulates interleukin-6 production in activated human macrophases, growth factors (2019) Doi: 10.1080/08977194.2019.1662418