Great roundup!

As the most common type of RNA modification in eukaryotes, N6-methyladenosine (m6A) can regulate functions such as RNA processing, splicing, maturation, export, stability, translation and degradation

Image credit: https://doi.

Recently, researchers from Nanjing Medical University published a paper entitled "Novel insights into the interaction between N6-methyladenosine modification and circular RNA" in the journal Molecular Therapy: Nucleic Acids.

Properties of M6A Circular RNAs

Previous studies have shown that RNase R-resistant (non-linear) RNAs contain strong m6A signals, suggesting that circRNAs may be modified by m6A

YTHDF2 is known to regulate mRNA stability by forming a complex with m6A mRNA

The role of m6A methylation in circular RNA

A growing number of studies have shown that m6A modification has multiple regulatory effects on circular RNAs, including their biogenic splicing, localization, trafficking, and degradation

m6A methylation regulates circRNA biogenesis m6A methylation regulates circRNA stability m6A methylation contributes to the translation of circRNA m6A modification controls circRNA immunity m6A methylation affects the biological function of circRNA

The role of m6A methylation in circular RNA

Image credit: https://doi.

This review summarizes the properties and biological functions of m6A and circRNAs, focusing on the latest research progress on the interaction of m6A modification and circRNAs, providing a new perspective for understanding the complex regulatory network between RNA transcription and epigenetic modification

In addition, circRNAs can affect m6A levels through competitive binding or direct acquisition of m6A regulatory proteins

references

Tao Xu et al.