Great roundup!

Tumorigenesis is a complex process caused by successive genetic and epigenetic changes

Long non-coding RNAs (lncRNAs) are a class of single-stranded RNA molecules larger than 200 nucleotides, which are important components of tumor and immunology molecular networks

Image credit: https://pubmed.

Recently, researchers from Sichuan University published a review article entitled "The Role of Long Non-Coding RNAs in the Tumor Immune Microenvironment" in Frontiers in Immunology.

Biogenesis and Function of LncRNA

Non-coding RNA (Non-coding RNA) refers to functional RNA molecules that are difficult to translate into proteins

The origin of lncRNAs is unclear, and possible origins have been confirmed: (a) protein-coding gene mutations; (b) chromosomal rearrangements: recombination of isolated gene sequences can generate lncRNAs; (c) repeats: adjacent structural units in the lncRNA sequence Duplications increase the length of the transcript; (d) Transposon insertion: A transposon containing a transcription initiation site is inserted into the genome, resulting in a functional lncRNA sequence

LncRNA functional mechanism and tumor immune microenvironment

LncRNAs regulate their targets through multiple mechanisms, both at the transcriptional and post-transcriptional levels

LncRNA functional mechanism and tumor immune microenvironment

Image credit: https://pubmed.

This study looks forward to the challenges and future development directions of lncRNA-based immunotherapy

In addition, the use of multidrug cancer immunotherapy to optimize long-term survival is promising

references

Yingli Guo et al.