Great progress in the analysis of human protein map

According to foreign media reports, the latest issue of science has published large analysis results based on human protein map, including detailed protein map related to cancer, protein type and quantity in blood, and target protein of all approved drugs on the market The human protein atlas is a large transnational research project supported by Knut and Alice Wallenberg foundation in November 2014 Recently, they have opened a protein map database based on human organs and tissues Based on 13 million annotated images, the whole database covers the protein distribution of all the main tissues and organs in the human body, and also marks the protein only expressed in specific tissues, such as brain, heart or liver As an open data resource, this database improves the basic understanding of human biology, and is expected to help promote new diagnosis and drug development In this article of science, "tissue-based human proteome map" combines genomics, transcriptome, proteomics, and antibody based analysis to analyze about 20000 protein coding genes in detail The results showed that almost half of the protein coding genes were generally expressed in all analyzed tissues About 15% of protein coding genes are expressed in one or several specific tissues or organs, including well-known tissue-specific proteins, such as insulin and troponin Testicles are the most protein rich organs, followed by the brain and liver The results also showed that about 3000 proteins were secreted from the cells, and another 5500 proteins were located in the membrane structure This protein map analysis results provide important information for the pharmaceutical industry The team's Uhl é n said they found that 70% of the drugs used on the market target secreted or membrane bound proteins Interestingly, another 30% of them were found to act on other tissues and organs, which may help to explain some side effects of the drug and provide some reference value for the future drug development.