Grape seed extract improves the colon injury induced by PhIP in rats by regulating the intestinal flora, lipid metabolism and NF-κB signaling pathway

Recently, the team of Professor Zhang Yan and Professor Wang Shuo of Nankai University published an online article titled "Grape seed extract ameliorates PhIP-induced colonic injury by modulating gut microbiota, lipid metabolism, and NF-κB signaling pathway in rats" in the Journal of Functional Foods.

Focus:

Grape seed extract (GSE) improves 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (2-Amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine, PhIP) induced oxidative stress and DNA damage.

GSE improves the intestinal flora disorder caused by PhIP.

GSE improves lipid metabolism disorders caused by PhIP.

The NF-κB signaling pathway is involved in the process of colon protection.

Summary

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is rich in protein A common carcinogen produced during thermal processing of foods.

Corresponding author profile

Professor Zhang Yan

Zhang Yan, first-level candidate of 131 Innovative Talent Project, PhD supervisor

1.

1989.

1994.

2001.

2.

1997.

1999.

2004.

2009.

2009.

2018.
01—present, Professor of Nankai University

3.
Research direction

1.
The production mechanism of health hazards in the process of food processing, the mechanism of hazard action and dietary nutrition intervention; 2.
The quality and safety control technology of the food processing process; 3.
The new technology of rapid food safety detection.

Professor Wang Shuo

Wang Shuo, winner of the National Science Fund for Distinguished Young Scholars, a doctoral supervisor, a leader in scientific and technological innovation of the National "Ten Thousand Talents Program", enjoys a special allowance from the State Council.
He is an expert in the "Eleventh Five-Year" National Science and Technology Support Program "Key Food Processing Technology Research and Industrialization Development" expert group expert, "Twelfth Five-Year" National High-Tech Research and Development Plan ("863" Plan), food manufacturing in the field of modern agricultural technology Experts from the expert group on topics related to safety technology, chairman of the Youth Science and Technology Committee of the Chinese Society of Food Science and Technology Currently serving as a member of the editorial board of LWT-Food Science and Technology, Journal of Agricultural and Food Chemistry and other academic journals.
As the first completer, he won 1 second prize of National Science and Technology Progress Award and 1 first prize of Tianjin Science and Technology Progress Award.

Research direction (including undertaking research projects):

1.
Research and development of small molecule immunoassay theory and new detection technology; 2.
"Bionic antibody" synthesis and reaction mechanism and alternative biological antibody immunoassay theory and detection technology; 3.
Research and development of food processing quality and safety control technology ; 4.
Food safety risk assessment.

The article "Grape seed extract ameliorates PhIP-induced colonic injury by modulating gut microbiota, lipid metabolism, and NF-κB signaling pathway in rats" was published online in the Journal of Functional Foods.