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On July 16, UPHW added 2 new registration numbers, one from the suppliers of calcium phosphate from Budenheim in Germany and Polyclinic potassium from Purolite in the United Kingdom.
.
Polaklin potassium parameters:
Polymer: potassium salt of 2-methyl-2-acrylic acid and divinylbenzene polymer Potassium content: 20.
6%~25.
1% Ion form: K-type functional group: carboxylic acid
Particle size: ＞75μm: ≤30%
> 150 m: ≦ 1%
polacrilin potassium Applications: polacrilin potassium years tablet disintegrating agents are incorporated in the formulation, is still widely used alone or used in conjunction with other products
.
Polyclinic potassium can be mixed and used.
When in use, the dry powder of this product is mixed with API and then compressed into tablets
.
In the formula, it can be added in the proportion of 0.
5 to 5%, and more can be added if necessary
.
This product swells about 150% when wet, which causes the tablet to disintegrate quickly without agglomerating into agglomerates
.
When the disintegration effect is the same, the dosage is much smaller than the recommended dosage of other disintegrants
.
And the high-efficiency disintegration ability of this product when it comes into contact with water has nothing to do with temperature
.
Adding a suitable surfactant (about 0.
2%) to the formulation will make the disintegration effect more rapid and ideal
.
In addition, the application of polyclinic potassium can enhance the physical strength of the tablet, so the hardness of the compressed tablet can more easily meet the requirements
.
Calcium phosphate
Budenheim calcium phosphate (CAS: 12167-74-7 ) : F20190000688Direct pressure anhydrous calcium phosphate ( Ca 5 (PO 4 ) 3 OH ): thinner
10% suspension pH: 6.
High powder porosity: about 80%
High specific surface area: about 85 ㎡/g
D50: 100 μm
Bulk density: 0.
Tap density: 0.
1.
For details, see article: Study on the improvement of tablet performance by calcium phosphate TRI-CAFOS 500
Pollacrine Potassium
Purolite production polacrilin potassium, and potassium, is a dry powder form weakly acidic cation exchange resin polymethacrylic acid , model Puolite ® C115KRM , CAS: 65405- 55-2 , registration number: F20210000083.
Polaklin potassium parameters:
Polymer: potassium salt of 2-methyl-2-acrylic acid and divinylbenzene polymer Potassium content: 20.
6%~25.
1% Ion form: K-type functional group: carboxylic acid
Particle size: ＞75μm: ≤30%
> 150 m: ≦ 1%
polacrilin potassium Applications: polacrilin potassium years tablet disintegrating agents are incorporated in the formulation, is still widely used alone or used in conjunction with other products
.
Polyclinic potassium can be mixed and used.
When in use, the dry powder of this product is mixed with API and then compressed into tablets
.
In the formula, it can be added in the proportion of 0.
5 to 5%, and more can be added if necessary
.
This product swells about 150% when wet, which causes the tablet to disintegrate quickly without agglomerating into agglomerates
.
When the disintegration effect is the same, the dosage is much smaller than the recommended dosage of other disintegrants
.
And the high-efficiency disintegration ability of this product when it comes into contact with water has nothing to do with temperature
.
Adding a suitable surfactant (about 0.
2%) to the formulation will make the disintegration effect more rapid and ideal
.
In addition, the application of polyclinic potassium can enhance the physical strength of the tablet, so the hardness of the compressed tablet can more easily meet the requirements
.
