Good news! Good vitamin D status can prevent cancer!

, June 18, 2020 /PRNewswire-bio-valley,, says good vitamin D status is beneficial for cancer prevention and prognosis for several types of cancer, according to a new studyThe anti-cancer effects of vitamin D are particularly significant in the prevention and treatment of colon and blood cancersIn addition, high reactivity in vitamin D is associated with a lower risk of cancerDifferent individuals respond differently to vitamin D, which affects their need for vitamin D supplementationby Professor Carsten Carlberg of the University of Eastern Finland and Alberto Mu? Professor Oz's review, published in the Journal of Cancer Biology, provides the latest developments in the molecular basis of vitamin D signals and their role in cancer prevention and treatmentpicture source: The important role of vitamin D in bone health is well known, but the authors note that vitamin D also regulates the immune system, and its anti-cancer effects are mainly mediated by immune cells, such as mononucleosis and T cellsVitamin D works through vitamin D receptors (VDRs), a transcription factor that participates in many gene expression and epigeneticgeneticregulationBased on this review, studies on the effects of vitamin D on different types of cancer provide the strongest evidence that it is beneficial for colorectal and blood cancers such asleukemiaand lymphomaVitamin D plays an important role in the differentiation of blood cells in the hematopoietic process and for adultstem cells
in rapidly regenerated tissues such as colons or skin Low vitamin D can lead to poor VDR function, increasing the risk that these cells will not fully differentiate and begin to become uncontrolled lying cancer cells even in other types of cancers, such as breast cancer and prostate cancer, low vitamin D levels, i.e 25-hydroxy vitamin D levels in the blood, are associated with higher cancer incidence and poor prognosis However, in randomized controlled trials, vitamin D supplementation did not consistently show that cancer mortality could be reduced According to the authors of the review, the effects of vitamin D could be shown more clearly if participants were stratified according to their individual response levels and health outcomes analysis to changes in individual vitamin D status Professor Carlberg's team has shown earlier that individuals have different molecular responses or sensitivities to vitamin D supplements For example, 25% of the Finnish population appears to be low-reactive and require higher doses of vitamin D supplements to achieve full clinical outcomes In terms of cancer risk, vitamin D can be predicted as a high responder according to the review, good vitamin D status is beneficial for general cancer prevention But there is little evidence that it is useful in treating cancer (BioValleyBioon.com) References: Agood vitamin D status can rinscancer
Carsten Carlberg et et al.
An update on vitamin d signaling and cancer , Seminars in Cancer Biology (2020) DOI: 10.1016/j.semcancer.2020.05.018