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This study can shed some light on
it
Executive Summary
On November 15, 2022, researchers at the University of Nottingham published new findings at Advantage Biomaterails show that there is a new polymer that can provide instructions to immune and non-immune cells to promote wound healing
in diabetics.
Study screenshots
status quo
involving the interaction between various cells, including structural, stromal and immune cells.
It is mainly composed of four sequential stages:
1.
hemostatic phase - infiltrating cells form scaffolds while storing relevant growth factors; 2.
Inflammatory stage - immune cell infiltration, phagocytosis and microorganisms, and secretion of cytokines to promote the proliferative period; 3.
Cell proliferation and migration stage - the proliferation and migration of fibroblasts, myofibroblasts and endothelial cells to form granulation tissue, of which fibroblasts are the most common cell type; 4.
Remodeling stage - fibroblasts secrete structural extracellular matrix, form mature scar tissue or regenerate skin
.
Diseases such as diabetes can cause dysregulation of these biological processes, wound healing is chronically in an inflammatory phase, cells in the wound microenvironment exhibit dysregulation of pro- and anti-inflammatory cytokines and impaired
angiogenesis.
Fibroblasts in the wound manifest a decrease in extracellular matrix synthesis, decreased cell migration and proliferation capacity, prevented granulation from forming, and caused wounds to not heal
normally.
conclusion
that effectively regulate fibroblast differentiation in the direction of promoting/inhibiting cell proliferation.
The results show:
- Through quantitative analysis of cell proliferation index and fibroblastic marker α-SMA, polytetrahydrofurfuryl acrylate (pTHFuA) promotes proliferation and inhibits differentiation, while polyethylene glycol phenyl ether acrylate (pEGPEA) inhibits proliferation and promotes differentiation
.
Therefore, they designated pTHFuA as a pro-proliferation polymer and pEGPEA as an anti-proliferative polymer
. - Scratch testing was used to analyze how anti-proliferative and pro-proliferative polymers affect wound healing
.
After 48 h, fibroblasts on proproliferative surfaces invaded 48% of the initial "wound" area, while fibroblasts on antiproliferative surfaces invaded 35%.
At 96 hours, the wound healing rate on proproliferative surfaces was 82%, compared with 55%
on antiproliferative surfaces.
This observation demonstrates the function
of proliferative polymers to accelerate fibroblast proliferation and migration, thereby wound healing. - Proliferating polymers allow fibroblasts to maintain higher cell viability
.
The number of fibroblasts cultured for 96 hours using proproliferative polymers increased by about 3 times
compared with anti-proliferative polymers. - The gene expression levels of collagen I and collagen III of fibroblasts cultured by proproliferative polymers were significantly lower than those of antiproliferative polymers, suggesting that proproliferative polymers produced anti-fibrosis and scarless wound healing response
.
prospect
Professor Amir Ghaemmaghami, from the School of Life Sciences at the University of Nottingham, corresponding author of the study, said: "This research is an important step towards creating a new,
low-cost and effective treatment for diabetic wounds.
Professor Morgan Alexander from the University of Nottingham's School of Pharmacy added:
- Our previous research work has demonstrated the medical potential of novel polymers, for example, we have successfully applied antimicrobial biofilm materials to urinary catheters to prevent infection
by altering the cellular behavior of bacteria on polymer surfaces. - We believe that the biopolymers in this study can be applied to dressings, and we have worked with relevant partners to seek treatments and research
related to promoting wound healing.
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