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Supplementing the body's high-density lipoprotein (HDL) may be an effective treatment for sepsis, according to a new study published in Science Signaling at the University of Kentucky School of Medicine
Laboratory research led by Dr.
Sepsis is a life-threatening disease that occurs when an infection sets off a chain reaction throughout the body
HDL cholesterol is called "good" cholesterol because it helps remove other forms of cholesterol from the blood
In collaboration with co-investigators at the University of Michigan Hospital's Intensive Care Unit, the study showed that septic patients had lower levels of HDL cholesterol compared to non-septic patients
According to this study, combined with Li's previous studies in HDL-deficient mice, these findings suggest that reduced HDL abundance is a risk factor for sepsis, and that increasing HDL abundance may provide a viable strategy for treating sepsis
To test this hypothesis, Li's team treated mice with sepsis with a synthetic HDL called ETC-642.
"Overall, these data suggest that HDL therapy may be an effective treatment for sepsis," Li said
ETC-642 was previously developed for the treatment of cardiovascular disease and has been shown to be effective in raising HDL levels in patients in several clinical trials
