Ginkgo not anti dementia will be poisoned?

Business news on December 14: at present, an estimated 18 million people around the world suffer from Alzheimer's disease (Alzheimer's disease), which has become a major disease threatening the health of the elderly Medical scientists all over the world focus on the study of dementia, and people and patients are not idle, looking for "panacea" to prevent dementia Therefore, Ginkgo biloba has become a popular anti dementia "Star" Ginkgo biloba extract preparation has flooded the market, and it is also popular among the people to use Ginkgo biloba to soak water and use ginkgo fruit (Ginkgo biloba) to make soup and porridge However, in recent years, a number of rigorous scientific research has poured cold water on Ginkgo biloba, which may not have any effect, but its toxicity deserves people's attention Ginkgo biloba passes blood vessels, so anti dementia? Ginkgo biloba, known as Ginkgo biloba in ancient times, is regarded as treasure all over the body Its leaves and fruits have been used as medicine for more than 2000 years According to the records of diet therapy materia medica and compendium of Materia Medica, Ginkgo biloba leaf can be used for "palpitation, palpitation, palpitation and palpitation", "deficiency of lung, cough and asthma" and other diseases In the market, Ginkgo biloba and Ginkgo biloba extract have been sold as memory enhancing drugs to a large number of buyers According to China dementia and cognitive impairment diagnosis and treatment guidelines 2011, some studies have found that Ginkgo biloba has a slight therapeutic effect on Alzheimer's disease, which can improve the neuropsychological symptoms of patients and delay the course of dementia Professor Xu Wuhua, director of Rehabilitation Department of Guangzhou Red Cross Hospital (the Second District of Neurology), said that laboratory research found that Ginkgo biloba contains flavonoids active substances which can scavenge free radicals and have been used for the treatment of cardiovascular and cerebrovascular diseases for a long time There is a theory of the origin of blood vessels in the etiology of Alzheimer's disease In recent years, it has been found that the risk factors of atherosclerosis play an important role in the pathogenesis of Alzheimer's disease There is no absolute limit between this disease and vascular dementia induced by atherosclerosis Therefore, it is believed that Ginkgo biloba preparation may also have the effect of anti dementia Evidence based medicine does not support anti dementia effect of Ginkgo biloba China dementia and cognitive impairment diagnosis and treatment guidelines 2011 also pointed out that some tests believed that Ginkgo biloba had no effect on dementia For example, the United States carried out a six-year randomized, double-blind, placebo-controlled trial from 2000 to 2009 The results showed that Ginkgo biloba extract could not effectively reduce the probability of Alzheimer's disease in normal elderly or patients with mild cognitive impairment 。 Therefore, whether Ginkgo biloba can prevent and treat dementia is still uncertain Recently, the international authoritative medical journal Lancet published a French study with a sample of up to 2845 people over five years, saying that it is invalid to prevent or delay Alzheimer's disease by taking Ginkgo biloba or Ginkgo biloba extract The old people in the study were basically over 70 years old, with memory problems Half of them took Ginkgo biloba extract twice a day, the other half took placebo Five years later, 4% of the people in the ginkgo group suffered from Alzheimer's disease, which was not significantly different from those who did not take Ginkgo biloba "This is by far the largest experiment on Ginkgo biloba, and the results are disappointing It does not reduce the risk of Alzheimer's disease," said edzede Ernst, a professor at the University of Exeter in the UK Dr long Schneider, an expert in Alzheimer's disease research in the United States, said that nearly 10000 people have participated in the experiment of Ginkgo biloba's effect on improving memory or promoting brain activity "The research on this substance is very extensive, but no experiment shows that it can improve or delay memory decline." According to Xu Wuhua's evaluation of the above experiments, those are large-scale, multicenter, randomized, double-blind and controlled studies, and the conclusions meet the requirements of evidence-based medicine, which are very convincing He said that there are many causes of dementia, such as depression, brain injury, hyperlipidemia, hypertension, carbon monoxide poisoning and so on Ginkgo biloba can only act on individual factors, even if it has preventive effect He did not object to the patients trying ginkgo preparations, or drinking water with ginkgo leaves, using ginkgo fruit Baiguo soup, but he did not agree to simply use Ginkgo biloba to prevent and treat dementia Some businesses exaggerate the curative effect of Ginkgo biloba Patients should not hold too much hope, let alone replace the medicine prescribed by doctors with Ginkgo biloba "There is no Chinese patent medicine that can prevent dementia for a long time Ginkgo biloba, Ganoderma lucidum, Cordyceps and so on are unscientific, may be useful, but the ingredients of psychological comfort are more." However, Xu Wuhua also pointed out that at present, there are some defects in the design of foreign experimental studies on Ginkgo intervention in dementia For example, the time of taking ginkgo is too late, the time of observation is too short, and the anti dementia effect of Ginkgo can not be completely denied He suggested that the best way to prevent dementia is to start with a lifestyle: a balanced diet, a happy mood and a positive attitude, regular exercise, regular health examination, and avoid smoking, staying up late and other unhealthy lifestyle Ginkgo biloba may be poisoned by eating Ginkgo biloba and soaking Ginkgo biloba leaves It is found that Ginkgo biloba contains Ginkgo toxin Excessive consumption of raw or fried food can lead to poisoning, especially in children Poisoning occurs 1-12 hours after taking the medicine The symptoms are fever, vomiting, abdominal pain, diarrhea, convulsion and dyspnea The severe cases may die of respiratory failure A few people may have sensory disorders and lower extremity paralysis The results showed that Ginkgo biloba has the function of inhibiting platelet, and it can cause serious bleeding after long-term and large dose application Ginkgo biloba leaves also have certain toxicity, and its toxic components are water-soluble substances such as white fruit acid, hydrocyanic acid and histamine, while the active component flavonoids in Ginkgo biloba leaves are mostly insoluble in water Therefore, the people directly drink ginkgo leaf tea not only can not get the active ingredients, but also may be toxic ingredients.