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▎Editor of WuXi AppTec content team We all know that exercise is good for health
.
In addition to strengthening muscles, cardiovascular, etc.
, exercise also has a positive impact on brain health
.
Recently, scientists at Harvard University Medical School and Massachusetts General Hospital have discovered through experiments that a hormone released by muscles, irisin, is a key regulator of exercise to enhance brain cognitive function
.
Their research paper published in the academic journal "Nature-Metabolism" pointed out that this exercise hormone is expected to be used to treat cognitive decline caused by aging or Alzheimer's disease (AD)
.
Professor Bruce Spiegelman, one of the authors of this research paper, is one of the discoverers of irisin
.
In 2012, he and his colleagues published an article in the journal Nature, stating that exercise stimulates muscles to express a membrane protein called FNDC5
.
The peptide substance released into the blood circulation after FNDC5 is cleaved, namely irisin, is a new hormone that can promote metabolic health
.
Image source: Experiments carried out by the 123RF research team on mice showed that mice that lost the Fndc5 gene and lacked irisin exhibited cognitive decline during exercise, aging and the development of Alzheimer's disease
.
Irisin is involved in the production of new neurons in the brain
.
Researchers analyzed the brain neurons of these genetically defective mice and found that the hippocampus, a brain area closely related to memory storage, is also the brain area that bears the brunt of Alzheimer's disease.
The neurons that are newly born in adulthood are in shape.
Abnormalities in, function and gene expression may be a cause of impaired cognitive function
.
Image source: 123RF Fortunately, after researchers supplemented mice with irisin, their cognitive deficits were remedied
.
In several Alzheimer’s disease model mice, the researchers overexpressed genes by targeting the adeno-associated virus (AAV) in the liver to increase the level of irisin in the blood of the mice, and found that it can make the central nervous system The level of irisin increases and improves the cognitive function of the brain in mice
.
"We have seen the effect of irisin on cognitive function in four different mouse models, which makes the research results particularly credible
.
" Professor Spiegelman emphasized
.
Even more exciting is that even though Alzheimer's disease model mice have shown obvious neuropathological signs, they can be improved by supplementing them with irisin
.
This allows researchers to see the potential of using irisin to intervene in Alzheimer's disease in humans, because patients with Alzheimer's disease usually start treatment after they develop symptoms
.
The researchers found that this may be because irisin can directly act on glial cells in the brain to avoid neuroinflammation
.
Image source: Professor Rudy Tanzi, one of the authors of the 123RF paper, is an expert on Alzheimer’s disease and neuroinflammation.
He pointed out: “With aging, neuroinflammation may be the most harmful factor to brain neurons.
Our discovery is to resist Neuroinflammation provides a new mechanism
.
It is hard to imagine anything more beneficial to brain health than daily exercise
.
"Dr.
Christiane Wrann, the corresponding author who led the study, added: "Since irisin does not specifically target amyloid plaques, but directly targets neuroinflammation, we are optimistic that, in addition to Alzheimer’s disease, irisin has effects on other Neurodegenerative diseases will also have beneficial effects
.
"Reference: [1] Mohammad R.
Islam et al.
, (2021) Exercise hormone irisin is a critical regulator of cognitive function.
Nature Metabolism Doi: https://doi.
org/10.
1038/s42255-021-00438-z [2] The hormone irisin is found to confer benefits of exercise on cognitive function Retrieved Sep.
7, 2021 from https:// -confer-benefits-of-exercise-on-cognitive-function[3] Pontus Boström et al.
, (2012) A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Nature.
Doi : https://doi.
org/10.
1038/nature10777
.
In addition to strengthening muscles, cardiovascular, etc.
, exercise also has a positive impact on brain health
.
Recently, scientists at Harvard University Medical School and Massachusetts General Hospital have discovered through experiments that a hormone released by muscles, irisin, is a key regulator of exercise to enhance brain cognitive function
.
Their research paper published in the academic journal "Nature-Metabolism" pointed out that this exercise hormone is expected to be used to treat cognitive decline caused by aging or Alzheimer's disease (AD)
.
Professor Bruce Spiegelman, one of the authors of this research paper, is one of the discoverers of irisin
.
In 2012, he and his colleagues published an article in the journal Nature, stating that exercise stimulates muscles to express a membrane protein called FNDC5
.
The peptide substance released into the blood circulation after FNDC5 is cleaved, namely irisin, is a new hormone that can promote metabolic health
.
Image source: Experiments carried out by the 123RF research team on mice showed that mice that lost the Fndc5 gene and lacked irisin exhibited cognitive decline during exercise, aging and the development of Alzheimer's disease
.
Irisin is involved in the production of new neurons in the brain
.
Researchers analyzed the brain neurons of these genetically defective mice and found that the hippocampus, a brain area closely related to memory storage, is also the brain area that bears the brunt of Alzheimer's disease.
The neurons that are newly born in adulthood are in shape.
Abnormalities in, function and gene expression may be a cause of impaired cognitive function
.
Image source: 123RF Fortunately, after researchers supplemented mice with irisin, their cognitive deficits were remedied
.
In several Alzheimer’s disease model mice, the researchers overexpressed genes by targeting the adeno-associated virus (AAV) in the liver to increase the level of irisin in the blood of the mice, and found that it can make the central nervous system The level of irisin increases and improves the cognitive function of the brain in mice
.
"We have seen the effect of irisin on cognitive function in four different mouse models, which makes the research results particularly credible
.
" Professor Spiegelman emphasized
.
Even more exciting is that even though Alzheimer's disease model mice have shown obvious neuropathological signs, they can be improved by supplementing them with irisin
.
This allows researchers to see the potential of using irisin to intervene in Alzheimer's disease in humans, because patients with Alzheimer's disease usually start treatment after they develop symptoms
.
The researchers found that this may be because irisin can directly act on glial cells in the brain to avoid neuroinflammation
.
Image source: Professor Rudy Tanzi, one of the authors of the 123RF paper, is an expert on Alzheimer’s disease and neuroinflammation.
He pointed out: “With aging, neuroinflammation may be the most harmful factor to brain neurons.
Our discovery is to resist Neuroinflammation provides a new mechanism
.
It is hard to imagine anything more beneficial to brain health than daily exercise
.
"Dr.
Christiane Wrann, the corresponding author who led the study, added: "Since irisin does not specifically target amyloid plaques, but directly targets neuroinflammation, we are optimistic that, in addition to Alzheimer’s disease, irisin has effects on other Neurodegenerative diseases will also have beneficial effects
.
"Reference: [1] Mohammad R.
Islam et al.
, (2021) Exercise hormone irisin is a critical regulator of cognitive function.
Nature Metabolism Doi: https://doi.
org/10.
1038/s42255-021-00438-z [2] The hormone irisin is found to confer benefits of exercise on cognitive function Retrieved Sep.
7, 2021 from https:// -confer-benefits-of-exercise-on-cognitive-function[3] Pontus Boström et al.
, (2012) A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Nature.
Doi : https://doi.
org/10.
1038/nature10777
