Genotype I African swine fever virus has invaded our country’s field pigs and can cause

Recently, the National African Swine Fever Professional Laboratory of Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences reported for the first time that the genotype I African swine fever virus has invaded our country's field pigs and can cause chronic infections

At least 24 genotypes of African swine fever virus have been identified worldwide, most of which are prevalent in Africa

In the process of epidemiological surveillance and pathogenic research, the scientific researchers of the National African Swine Fever Professional Laboratory isolated two genotype I African swine fever virus SD/DY-I/ from clinically ill pig samples from pig farms in Shandong and Henan.

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Figure 1: Comparative analysis of the whole genome of SD/DY-I/21 and HeN/ZZ-P1/21 with European and African early genotype I isolatesFZS China Feed Industry Information Network-Based on feed, serving animal husbandry

Comparison of SD/DY-I/21 and HeN/ZZ-P1/21 whole genomes with genotype I virulent strains L60, Benin 97 and low lethal strains NH/P68 and OURT88/3 isolated from Europe and Africa early, all ORFs Deletions, shortening and extension changes (A); compared with the low lethal strains NH/P68 and OURT88/3, nucleotide mutations in the coding region (B), deletions, insertions and substitutions (C), and non-coding regions Nucleotide mutations, deletions and insertions (D)

Animal experiments show that SD/DY-I/21 infected pigs have low pathogenicity and high transmission ability, which can cause chronic clinical symptoms such as necrotizing skin damage and joint swelling (Table 1 and Figure 2)

Table 1: Clinical symptoms of artificially infected pigs and cohabiting pigs with genotype I isolate SD/DY-I/21FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

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Two cohabiting SPF pigs were set up in the two dose infection groups respectively, and all of them survived during the 28-day observation period

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Figure 2: Genotype I isolate SD/DY-I/21 causes chronic infectionFZS China Feed Industry Information Network-Based on feed, serving animal husbandry

The genotype I isolate SD/DY-I/21 artificially infected SPF pigs with skin papules (A and B), skin necrosis (B and C) and arthritis (B and D)

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Figure 3: Genotype I isolate SD/DY-I/21 artificially infected pigs and their cohabiting pigs mouth, anal swab and blood virus DNA detectionFZS China Feed Industry Information Network-Based on feed, serving animal husbandry

Genotype I African swine fever virus has invaded our country, making the population of African swine fever virus in the field more complicated

 　　Sun Encheng, Huang Lianyu, Zhang Xianfeng, Zhang Jiwen and Shen Dongdong are the co-first authors of the paper, and Bu Zhigao and Zhao Dongming are the co-corresponding authors

　　Full text link: https:// China Feed Industry Information Network-Based on feed, serving animal husbandry

 　　At least 24 genotypes of African swine fever virus have been identified worldwide, most of which are prevalent in Africa

 　　In the process of epidemiological surveillance and pathogenic research, the scientific researchers of the National African Swine Fever Professional Laboratory isolated two genotype I African swine fever virus SD/DY-I/ from clinically ill pig samples from pig farms in Shandong and Henan.

FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

Figure 1: Comparative analysis of the whole genome of SD/DY-I/21 and HeN/ZZ-P1/21 with European and African early genotype I isolatesFZS China Feed Industry Information Network-Based on feed, serving animal husbandry

 　　Comparison of SD/DY-I/21 and HeN/ZZ-P1/21 whole genomes with genotype I virulent strains L60, Benin 97 and low lethal strains NH/P68 and OURT88/3 isolated from Europe and Africa early, all ORFs Deletions, shortening and extension changes (A); compared with the low lethal strains NH/P68 and OURT88/3, nucleotide mutations in the coding region (B), deletions, insertions and substitutions (C), and non-coding regions Nucleotide mutations, deletions and insertions (D)

 　　Animal experiments show that SD/DY-I/21 infected pigs have low pathogenicity and high transmission ability, which can cause chronic clinical symptoms such as necrotizing skin damage and joint swelling (Table 1 and Figure 2)

Table 1: Clinical symptoms of artificially infected pigs and cohabiting pigs with genotype I isolate SD/DY-I/21FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

　　Two cohabiting SPF pigs were set up in the two dose infection groups respectively, and all of them survived during the 28-day observation period

FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

Figure 2: Genotype I isolate SD/DY-I/21 causes chronic infectionFZS China Feed Industry Information Network-Based on feed, serving animal husbandry

FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

Figure 3: Genotype I isolate SD/DY-I/21 artificially infected pigs and their cohabiting pigs mouth, anal swab and blood virus DNA detectionFZS China Feed Industry Information Network-Based on feed, serving animal husbandry

 　　Genotype I African swine fever virus has invaded our country, making the population of African swine fever virus in the field more complicated
.
Although this type of virus has a low fatality rate, it can cause chronic infection in pigs and has a strong horizontal transmission ability
.
Due to the slow course of the disease, the diverse clinical manifestations, and the more concealed nature, coupled with the poor regularity of detoxification and viremia, it is difficult for early diagnosis and new challenges for the prevention and control of African swine fever.
It should be paid attention to and formulated as soon as possible.
And take effective countermeasures
.
FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

 　　Sun Encheng, Huang Lianyu, Zhang Xianfeng, Zhang Jiwen and Shen Dongdong are the co-first authors of the paper, and Bu Zhigao and Zhao Dongming are the co-corresponding authors
.
FZS China Feed Industry Information Network-Based on feed, serving animal husbandry

　　Full text link: https:// China Feed Industry Information Network-Based on feed, serving animal husbandry