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Genome-wide screening identifies novel targets for the treatment of sorafenib-resistant hepatocellular carcinoma

 Last Update: 2022-05-18
 Source: Internet
 Author: User

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A study led by Xiujun Cai screened the whole genome of hepatoma cells (HepG2) under sorafenib treatment by the CRISPR/cas9 system, and screened the dominant gene KEAP1 for sorafenib resistance

Using bioinformatics tools and experimental validation, such as qPCR, FGF21 was found to be the most relevant downstream molecule of Nrf2 in the context of sorafenib resistance in hepatocellular carcinoma

The research was published in the journal Science China Life Sciences

Provided by Scientific China Press

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