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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Liz Zee Guide: The rapid progress of the past decade has shown that the imbalance of the gut microbiota is an important sign of rheumatoid arthritis (RA)
.
However, the relationship between the gut microbiota and the clinical improvement of RA disease activity is unclear
.
The results of this study indicate that changing the gut microbiota to improve clinical efficacy is expected to become a future treatment for RA
.
A new study by the Mayo Clinic Center for Individualized Medicine suggests that an important indicator of whether RA patients will improve during the course of their illness may depend to some extent on their intestines
.
This research was published in "Genome Medicine", and the paper is titled "Gut microbial determinants of clinically important improvement in patients with rheumatoid arthritis"
.
The study found that it is possible to predict the future development of patients with RA by focusing on the trillions of bacteria, viruses, and fungi that parasitize the gastrointestinal tract (that is, the gut microbiota)
.
The results of the study indicate that gut microbes are related to the prognosis of RA patients
.
"This is the first study to date to use gut microbial data to predict the clinical improvement of RA, rather than relying on preliminary tests or previous treatments
.
"Said Dr.
Jaeyun Sung, a computational biologist at the Mayo Clinic Center for Individualized Medicine and co-senior author of this study
.
RA is a chronic disease characterized by arthritis and joint pain, which will eventually lead to bone and cartilage erosion, Joint deformities and loss of mobility
.
This complex disease affects nearly 1.
3 million people in the United States
.
In this study, the research team used a method called "shotgun metagenomic sequencing" to analyze the stool samples of 32 RA patients A comprehensive and accurate genome analysis was performed
.
After analysis, the research team found that several characteristics of the gut microbiota are related to the prognosis of RA
.
Clinical rheumatologist John M.
Davis III at the Mayo Clinic is the co-senior of this study The author, who is particularly interested in inflammatory arthritis, said: "By observing the baseline profile of the intestinal microbiota of patients, we have observed that the characteristics of the microbiota between patients with signs of improvement and those with no signs of improvement are obvious.
Different
.
"Surprisingly, our data shows that according to the final clinical results, the intestinal microbiota not only starts from a different ecological state, but also grows and develops differently
.
"Dr.
Sung added
.
Next, by using deep learning artificial intelligence (AI), the researchers tested whether they can predict whether the patient can achieve clinical improvement
.
Overall, the accuracy of the prediction results reached 90%, thus proving the intestines The combination of Dao microbiota and artificial intelligence technology can theoretically become a means to predict the course of RA
.
Dr.
Davis said: "With further development, this biological indicator prognosis can identify those patients whose condition can be improved early through specific therapies.
, So as to save them from the treatment costs and treatment risks of other treatments that are unlikely to be effective
.
Conversely, these tools can detect patients whose disease symptoms are unlikely to improve, and perhaps allow clinicians to target and monitor them more closely
.
Although there is still a lot of work to be done, we are on the right path to advance our understanding of this disease in order to target RA patients
.
"For some time, scientists have suspected that the gut microbiota plays a role in the treatment of RA and many other inflammatory and autoimmune diseases
.
A
large number of microorganisms help digest food, regulate the immune system, and defend against pathogenic bacteria
.
The researchers emphasized that each person’s microbiome is unique and is a mixture of genetics, diet, and environmental influences
.
These differences reveal the reasons for the large differences in symptoms between RA patients, which in turn makes treatment and prediction of clinical outcomes become Difficulty
.
This research is the second RA survey conducted by Dr.
Sung and Dr.
Davis recently.
It emphasizes the important cooperative relationship between computational biologists and clinicians in solving complex medical problems
.
Currently, they are jointly developing a set of New data-driven tools to help early detection, diagnosis, prognosis, and treatment of RA
.
Therefore, researchers plan to study ways to translate their findings into new biological indicators and treatments
.
“In the end, our research shows that changing the intestines Dao microbiota to improve clinical efficacy may be expected to become a method for the treatment of RA in the future," Dr.
Sung said
.
"This may completely change the way we care for patients
.
"Reference material: https://genomemedicine.
biomedcentral.
com/articles/10.
1186/s13073-021-00957-0 Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance, please go to the official Hospital visits
.
Popular·Article Scientific Research [NEJM] It’s time to change salt! Milestone research proves that simply changing salt can prevent millions of deaths every year.
Scientific research [Nature Sub-Journal] Unprecedented clarity and speed: new The microscopy technique recorded for the first time the activity of more than 1 million neurons in the entire mouse cerebral cortex.
Gene detection [Nature Sub-Journal] The 1.
5 million largest genome-wide association study identified nearly 600 related to antisocial behaviors, alcoholism, and opioids.
Gene locus related to drug addiction [NEJM Covid-19] The world's largest new coronavirus vaccine safety research results released liquid biopsy [Science sub-Journal] Biomarkers that can be determined based on blood samples-predict patient immunity Therapeutic response to the new coronavirus [new crown sequel] blockbuster: "So far the safest medicine for the treatment of new crown infection! "Clinical trial results are here! Organoids [Nature] The 3D brain organoids induced by stem cells can accurately replicate human brain cancer early screening [Nature Subs] A new non-invasive early screening method for lung cancer based on blood cfDNA, ultra-high detection Outcome rate! Organoids [Science sub-Journal] Subversion! For the first time, a complete living tumor was 3D printed, and cancer exploration has entered the "real" 3D era.
Gene editing [Nature Sub-Journal] Blockbuster! Academician Ye Yuru's team uses genome editing technology to treat Altz A major breakthrough in early cancer screening for Heimer's disease [The Lancet] Subverting traditional detection methods and achieving a new breakthrough in early prostate cancer screening.
Scientific research [Discovery] Recalculating the Nobel Prize winner's 1944 Vitamin C experimental data, and finding that it is recommended by WHO 2 times the dose recommendation·Activity The 3rd Shanghai International Cancer Conference The 5th Symposium on Modern Clinical Molecular Diagnosis
Please indicate the source for reprinting.
Author: Liz Zee Guide: The rapid progress of the past decade has shown that the imbalance of the gut microbiota is an important sign of rheumatoid arthritis (RA)
.
However, the relationship between the gut microbiota and the clinical improvement of RA disease activity is unclear
.
The results of this study indicate that changing the gut microbiota to improve clinical efficacy is expected to become a future treatment for RA
.
A new study by the Mayo Clinic Center for Individualized Medicine suggests that an important indicator of whether RA patients will improve during the course of their illness may depend to some extent on their intestines
.
This research was published in "Genome Medicine", and the paper is titled "Gut microbial determinants of clinically important improvement in patients with rheumatoid arthritis"
.
The study found that it is possible to predict the future development of patients with RA by focusing on the trillions of bacteria, viruses, and fungi that parasitize the gastrointestinal tract (that is, the gut microbiota)
.
The results of the study indicate that gut microbes are related to the prognosis of RA patients
.
"This is the first study to date to use gut microbial data to predict the clinical improvement of RA, rather than relying on preliminary tests or previous treatments
.
"Said Dr.
Jaeyun Sung, a computational biologist at the Mayo Clinic Center for Individualized Medicine and co-senior author of this study
.
RA is a chronic disease characterized by arthritis and joint pain, which will eventually lead to bone and cartilage erosion, Joint deformities and loss of mobility
.
This complex disease affects nearly 1.
3 million people in the United States
.
In this study, the research team used a method called "shotgun metagenomic sequencing" to analyze the stool samples of 32 RA patients A comprehensive and accurate genome analysis was performed
.
After analysis, the research team found that several characteristics of the gut microbiota are related to the prognosis of RA
.
Clinical rheumatologist John M.
Davis III at the Mayo Clinic is the co-senior of this study The author, who is particularly interested in inflammatory arthritis, said: "By observing the baseline profile of the intestinal microbiota of patients, we have observed that the characteristics of the microbiota between patients with signs of improvement and those with no signs of improvement are obvious.
Different
.
"Surprisingly, our data shows that according to the final clinical results, the intestinal microbiota not only starts from a different ecological state, but also grows and develops differently
.
"Dr.
Sung added
.
Next, by using deep learning artificial intelligence (AI), the researchers tested whether they can predict whether the patient can achieve clinical improvement
.
Overall, the accuracy of the prediction results reached 90%, thus proving the intestines The combination of Dao microbiota and artificial intelligence technology can theoretically become a means to predict the course of RA
.
Dr.
Davis said: "With further development, this biological indicator prognosis can identify those patients whose condition can be improved early through specific therapies.
, So as to save them from the treatment costs and treatment risks of other treatments that are unlikely to be effective
.
Conversely, these tools can detect patients whose disease symptoms are unlikely to improve, and perhaps allow clinicians to target and monitor them more closely
.
Although there is still a lot of work to be done, we are on the right path to advance our understanding of this disease in order to target RA patients
.
"For some time, scientists have suspected that the gut microbiota plays a role in the treatment of RA and many other inflammatory and autoimmune diseases
.
A
large number of microorganisms help digest food, regulate the immune system, and defend against pathogenic bacteria
.
The researchers emphasized that each person’s microbiome is unique and is a mixture of genetics, diet, and environmental influences
.
These differences reveal the reasons for the large differences in symptoms between RA patients, which in turn makes treatment and prediction of clinical outcomes become Difficulty
.
This research is the second RA survey conducted by Dr.
Sung and Dr.
Davis recently.
It emphasizes the important cooperative relationship between computational biologists and clinicians in solving complex medical problems
.
Currently, they are jointly developing a set of New data-driven tools to help early detection, diagnosis, prognosis, and treatment of RA
.
Therefore, researchers plan to study ways to translate their findings into new biological indicators and treatments
.
“In the end, our research shows that changing the intestines Dao microbiota to improve clinical efficacy may be expected to become a method for the treatment of RA in the future," Dr.
Sung said
.
"This may completely change the way we care for patients
.
"Reference material: https://genomemedicine.
biomedcentral.
com/articles/10.
1186/s13073-021-00957-0 Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance, please go to the official Hospital visits
.
Popular·Article Scientific Research [NEJM] It’s time to change salt! Milestone research proves that simply changing salt can prevent millions of deaths every year.
Scientific research [Nature Sub-Journal] Unprecedented clarity and speed: new The microscopy technique recorded for the first time the activity of more than 1 million neurons in the entire mouse cerebral cortex.
Gene detection [Nature Sub-Journal] The 1.
5 million largest genome-wide association study identified nearly 600 related to antisocial behaviors, alcoholism, and opioids.
Gene locus related to drug addiction [NEJM Covid-19] The world's largest new coronavirus vaccine safety research results released liquid biopsy [Science sub-Journal] Biomarkers that can be determined based on blood samples-predict patient immunity Therapeutic response to the new coronavirus [new crown sequel] blockbuster: "So far the safest medicine for the treatment of new crown infection! "Clinical trial results are here! Organoids [Nature] The 3D brain organoids induced by stem cells can accurately replicate human brain cancer early screening [Nature Subs] A new non-invasive early screening method for lung cancer based on blood cfDNA, ultra-high detection Outcome rate! Organoids [Science sub-Journal] Subversion! For the first time, a complete living tumor was 3D printed, and cancer exploration has entered the "real" 3D era.
Gene editing [Nature Sub-Journal] Blockbuster! Academician Ye Yuru's team uses genome editing technology to treat Altz A major breakthrough in early cancer screening for Heimer's disease [The Lancet] Subverting traditional detection methods and achieving a new breakthrough in early prostate cancer screening.
Scientific research [Discovery] Recalculating the Nobel Prize winner's 1944 Vitamin C experimental data, and finding that it is recommended by WHO 2 times the dose recommendation·Activity The 3rd Shanghai International Cancer Conference The 5th Symposium on Modern Clinical Molecular Diagnosis
