Genome Med: The abuse of antibiotics will cause immune enteritis.

1,2020 // --- In a recent study, researchers at Rutgers University found that giving young animals a single type of antibiotic for a short period of time may also make them more susceptible to inflammatory enteritis (IBD) in old age.
study, published in the journal Genome Medicine, provides further evidence to support the idea that the use of antibiotics in children under the age of one can damage the gut flora, leading to inflammatory enteritis and type 1 diabetes. "This study provides experimental evidence that the link between antibiotic exposure and the development of childhood disease in humans is not only related, but that they actually play a role in the causes of the disease," said Blaser, co-author of the
study.
" (photo: www.pixabay.com) To determine whether the increased risk of disease was caused by antibiotics destroying the microbiome, researchers studied the effects of exposure to sodium glucan sulfate, a chemical known to damage the colon, on mice receiving antibiotics and control groups.
they found that the colonitis in mice that received antibiotics themselves or microbiomes that were disturbed by antibiotics significantly worsened, suggesting that antibiotics alter the intestinal microbiome, alter the immune response of the colon, and worsen enteritis. Lead author Ceren Ozkul,
, said: "Using a fully validated model of colitis, we can study the effects of previous antibiotic exposures on the development of important disease processes.
this study continues Blaser's hypothesis that early-life-destroying microbiomes, especially through antibiotics and caesarean sections, are among the factors leading to the modern epidemic.
(Bioon.com) Source: Antibiotics use early life risk of the cricky disease row eth in life original origin: Ceren Ozkul, Victoria E. Ruiz, Thomas Battaglia, Joseph Xu, ClaireBaud-Baudron, Ken Cadwell, Guillermo I. Perez-Perez, A single early-in-life antibiotic course saued to DSS-induced colitis. Genome Medicine, 2020; 12 (1) DOI: 10.1186/s13073-020-00764-z.