GENETICS: Genetic mutations in the scariest predators can suppress cancer! Or the "saviour" of future humans!

Introduction: Cancer is generally not contagious, but the facial tumor disease of the kangaroo is transmitted to each other due to inbreeding.
that if the cancer continues to develop, they will become extinct within 25 years.
but the researchers have confirmed that the kangaroo has developed resistance to the cancer because of a genetic mutation.
previous studies have shown that kangaroo milk is key to fighting superbugs, and now a new study has shown the effects of genetic mutations on cancer, and the future of kangaroos will most likely be the human "saviour".
a pack of kangaroos, small and cute, live on the island of Tasmania in south-eastern Australia, but is known as the "Tasmanian Devil" because of its ferocious face and rotting habits.
was once the scariest predator in the world because of its ability to bite more than ferocious lions.
in fact, in Australian research institutions, after a long period of contact with researchers and determination that they are not malicious, the kangaroos will be quiet, and even sideways, enjoy the caress from humans.
more than 20 years, facial oncology (DFTD) has wreaked havoc on the kangaroo population.
DFTD is a cancer that can be transmitted through bites.
often bite each other as they compete for mates and food, and then solid tumors grow around the face or neck, even damaging the jawbone, and die after 6 to 24 months.
but over the past few years, the kangaroo has developed tolerance to infection and even resistance.
in response to the inference, researchers from the United States, Australia and other countries sequenced the genes of the kangaroo and compared the results with the genetic sequence of the kangaroo before the appearance of the kangaroo facial tumor disease.
results show that seven genes in the current life of the kangaroo have mutated, five of which are related to cancer or the immune system.
researchers speculate that these genetic mutations may have helped the kangaroo better protect against the kangaroo's facial tumor disease.
bags are very susceptible to facial cancer.
, the number of kangaroos has fallen by 80 per cent since 1996, and almost all of the decrease can be attributed to deaths from the disease.
A recent study by scientists at Washington State University (WSU) and the Fred Hutchinson Cancer Research Center in Seattle found that a single genetic mutation in the kangaroo can lead to reduced growth of facial tumor disease (DFTD), providing new insights into the treatment of cancers such as prostate and colon cancer in humans.
their findings were recently published in the journal Genetics.
, led by WSU Biosciences Professor Dr Andrew Storfer and WSU Biosciences Professor Dr Mark Margres, revealed specific mechanisms for the decline of untreated spontaneous tumours in human cancer patients.
They used comparative and functional genomics to identify tumor genetic variants associated with tumor receding, and it was shown that a single mutation in the 5' non-translational region of the assumed tumor suppressor RASL11A significantly promoted tumor recedal.
they found that a single genetic mutation causes DFTD to grow less.
the gene has been linked to prostate and colon cancer in humans.
these findings offer the most immediate hope of saving the world's few kangaroos, these results may one day contribute to human health.
, the researchers were surprised to see in the lab that the mutation that causes the tumor to subside did not alter its function, but rather turned on a gene, the RAS gene, that slows the growth of tumor cells.
mutations in the RAS gene drive about a third of human cancers, including a high proportion of pancreatic, lung and colorectal cancers.
using genome-wide sequencing, the researchers identified near-fixed genotype differences between regressive tumors and non-regression tumors in the assumed anti-cancer gene RASL11A regulatory area.
Then, using transcriptional histology, they demonstrated that RASL11A was silent in wild, non-degenerative tumors, but activated in degenerative tumors, consistent with genotype data and the expression of RASL11A in human prostate and colon cancers.
, they used cell proliferation assays to show that the active rasl11A significantly affected the proliferation of introphy cancer cells in three of the four tumor cell linees studied.
the RAS pathway often changes in human cancer, the intensification of RASL11A may provide a therapeutic option for the kangaroo and provide a general mechanism for tumor suppression.
David Hockenbery, a cancer biologist at the Fred Hutchinson Cancer Research Center, points out that current human cancer treatments often remove every trace of a tumor through toxic or debilitating treatments.
if there was a way for the tumor to subside without cytotoxic therapy or deformation surgery, that would be a major step forward.
the future may save humanity after Australian scientists discovered that the peptides contained in the kangaroo's milk, also known as "devil's cow's milk", can kill deadly superbugs such as Staphylococcus ale.
in the devil's cow's milk comes from an antibacterial family called "poison" and is a natural antibiotic.
researchers at the University of Sydney scanned the genome of the kangaroo and found six natural antimicrobial peptides, which were refined, artificially copied and used in experiments, killing several viruses that are now known to be extremely deadly to humans.
, the new findings highlight RASL11A as a natural mechanism for tumor suppression and a potential target in cancer treatment.
the disease is largely fatal, researchers are seeing more and more tumors disappear in individual animals.
they also hope to find the effects of other promising mutations in degenerative tumors and learn something that can be used to understand and treat many human cancers.
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