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| Genetic characteristics of microglia in Alzheimer's disease revealed |
Science and Technology Daily (intern reporter Zhang Jiaxin) Recently, scientists from the Duke-National University of Singapore School of Medicine and Monash University in Australia discovered the gene expression characteristics of microglia related to the phagocytosis of amyloid plaques.
Alzheimer's disease is the most common form of dementia and is characterized by the accumulation of amyloid plaques in the brain.
In order to understand the molecular mechanism and differences between the microglia that phagocytose amyloid plaques and other microglia in Alzheimer’s disease, the research team used a microglia specifically targeted at phagocytic amyloid plaques The staining agent was used to examine the gene expression in the stained microglia.
Studies have shown that for microglia that do not take up amyloid, their gene expression pattern is most similar to that of aging microglia, which is considered to be a major participant in the pathogenesis of Alzheimer's disease.
"This process may be initially protective.
The team also used computational models to predict the molecular networks involved in the uptake of proteins by microglia and identified potential targets to aid drug development.
The first author of the paper, Gabriel Zhou, said that the relationship between HIF1a and cognitive decline in Alzheimer's disease remains to be fully studied.
