Genes can determine whether COVID-19 symptoms are severe!

May 28, 2020 /
Bio-ValleyBIOON/-- When some people are infected with coronavirus, they will only have mild or undetectable COVID-19 casesOthers develop severe symptoms and need to struggle for weeks with the help of a ventilator if they surviveDespite the concerted efforts of scientists around the world, doctors still don't know whyCan genetic differences explain differences in the symptoms and severity of COVID-19?to verify this, the researchers used computer models to analyze known geneticvariants in the human immune systemTheir modeling results suggest that, in fact, there are differences in people's DNA, which may affect their ability to respond to SARS-CoV-2 infectionsresearchwhen a virus infects human cells, the body activates an antiviral alert systemThese alerts identify virus intrusions and tell the immune system to send cytotoxic T cells (a type of white blood cells) to destroy infected cells in the hope of slowing infectionimage source: https://cn.bing.com
but not all alarm systems are the samePeople have different versions of the same genes -- called alleles -- some of which are more sensitive to certain viruses or pathogens than othersto test whether the different alleles of the alarm system could explain certain areas of the SARS-CoV-2 immune response, the researchers first retrieved a list of all the proteins that make up the coronavirus from an online database they then used existing computer algorithms to predict the effectiveness of different versions of antiviral alert systems to detect these coronavirus proteins why it is important
researchers test ingress alert systems known as human leukocyte antigen systems, or HLA Each person has multiple alleles that make up the HLA type Each allele encodes a different HLA protein These proteins are sensors in the alarm system that are identified by binding to various peptide chains, which form the coronavirus part of the protein, which is foreign to the body once the HLA protein binds to a virus or viral fragment, it transports the intruder to the cell surface These "marked" infected cells are killed by immune cells Generally speaking, the more viral peptides detected by HLAs in humans, the stronger the immune response We think of it as a more sensitive sensor in an alarm system the researchers' modeling results predict that some HLA types can be combined with large amounts of SARS-CoV-2 peptides, while others have few SARS-CoV-2 peptides In other words, some sensors may be better suited to SARS-CoV-2 than others If this is true, then a person's HLA allele may be a factor affecting the immune system's response to COVID-19 because the study used only one computer model to make these predictions, they decided to use clinical information about the SARS outbreak from 2002 to 2004 to test the results they found similarities in the effectiveness of alleles in identifying SARS and SARS-CoV-2 If the HLA allele does not seem to be good at identifying SARS-CoV-2, it is not good at identifying SARS Their analysis predicted that an allele called B46:01 was particularly harmful to SARS-CoV-2 and SARS-CoV To be sure, previous studies have shown that people who carry this allele are more likely to be infected with SARS virus and have a higher viral load than people who carry other HLA genes image source: https://cn.bing.com
what's next? based their study, the researchers believe that the mutation in the HLA gene is partly responsible for the large differences in the severity of infection in many COVID-19 patients These differences in the HLA gene may not be the only genetic factor affecting the severity of COVID-19, but they may be an important part of the problem It is necessary to further study how HLA types affect the severity of COVID-19 clinically and to test these predictions through actual cases Understanding how HLA-type variation affects the clinical course of COVID-19 can help identify high-risk groups of the disease The researchers are the first to evaluate the relationship between viral proteins using a wide range of HLA alleles Currently, researchers know little about the relationship between many other viruses and HLA types In theory, researchers could repeat this analysis to better understand the
genetic risks of many viruses currently or at risk in humans (BioValleyBioon.com) References: 1, Your Genes can can ifher the corona putviruses you are in hospital
Association of hlA Association sanad association sanad association of HLA Association sani association sanai association of hlA i with acute carly scarle corona corona virus virus 3) RefSeq: NCBI Source Source the of the HLA Class I Alleles Alleles With-Source, Andreires of Size, Affinity, and Immune