"Gene scissors" gels are expected to be used to suppress triple-negative breast cancer
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Last Update: 2020-12-27
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Source: Internet
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Author: User
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team at Boston Children's Hospital in the United States has developed a technique to wrap "gene scissors" in nanogels, using the "gene scissors" therapy to safely and effectively inhibit the growth of triple negative breast cancer.
Three-negative breast cancer refers to estrogen- and progesterone-like and human skin growth factors 2 three main therapeutic targets are negative breast cancer, accounting for 12% to 17% of all breast cancer, characterized by poor prognostic, strong drug resistance, high recurrence rate and low treatment methods.according to
, CRISPR gene editing technology, known as "gene scissors", can precisely locate and cut off gene site on DNA (deoxyribonucleic acid), can turn off a gene or introduce new gene fragments, so as to achieve the goal of cure. However, this technique has the difficulty of effectively transporting to the target: the use of viruses as vectors has a low load and easy to "infect" non-targeted cells, the use of ordinary cation polymers or lipid nanoparticles encased in cytotoxicity.
researchers tried to wrap the CRISPR load with a soft nanolipid gel made up of non-toxic fat molecules and hydrogels, and glued the load to the surface of the gel to direct the load to antibodies at the tumor site that identify and target specific targets of triple-negative breast cancer tumors.
The study, published in the latest issue of the National journal
, showed that with the help of this nanogel, "gene scissors" can "target" breast tumors and knock out the gene "lipid-carrying protein 2" that promotes tumor development and metastasis, editing efficiency of 81 percent, reducing tumor growth in mice by 77 percent, and the nanogel has no toxic side effects on normal tissue.
study showed that this flexible gel particle fuses with the tumor cell wall, sending CRISPR loads directly into the cell, increasing delivery and reducing side effects. Similar methods could also be used to treat childhood cancer and deliver traditional drugs, the researchers said. (Source: Xinhua News Agency Zhou zhou)
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