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Gastroenterology: Effects of different clinical remission criteria on recurrence rates in patients with ulcerative colitis

 Last Update: 2020-11-06
 Source: Internet
 Author: User

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Current clinically ulcerative colitis (UC) patients with clinical remission are a combination of patient-reported results and Mayo endoscopic score (MES) 0 or 1.
recently assessed the impact of adopting stricter mitigation definitions, endoscopic remission (MES0) and histological mitigation, on the risk of recurrence in UC patients.
This study is a systematic review of the UC adult queue study, which reported the relative and absolute risk of clinical recurrence of UC patients achieving different treatment goals based on MES (0vs1), histological disease activity, and endoscopic results.
this meta-study included 17 related studies and 2,608 UC remission patients.
the risk of recurrence in patients with a MES 0 score was reduced by 52% compared to MES 1 (RR s 0.48).
12-month recurrence rate was 28.7 percent for patients with MES 1, compared with 13.7 percent for MES 0 patients.
In 10 studies involving endoscopic remission in patients with MES 0, the risk of clinical recurrence in patients with histological remission was 63% lower than in patients with histological disease activity (RR-0.37), and the average clinical recurrence rate of histological remission patients was 5.0%.
study found that patients with ulcerative colitis achieved more stringent remission endpoints, such as endoscopy and histological remission, were more conducive to reducing the risk of recurrence.

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