Gastroenterology: Eat less high-sugar foods and sugary drinks during adolescence, or significantly increase the risk of colorectal cancer in adulthood!

According to the latest global cancer data for 2020 released by the World Health Organization, colorectal cancer (CRC) has become the third largest cancer in the world, and the age of patients is gradually getting younger.

Studies have shown that high sugar intake can promote colorectal cancer by causing insulin resistance, obesity and type 2 diabetes (a known risk factor for CRC).

Recently, researchers from the Harvard School of Public Health in the United States and the Seoul National University School of Medicine in South Korea published a study titled Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors in Gastroenterology , and found that adolescence has a large amount of Intake of high-sugar foods and SSB will significantly increase the risk of conventional adenomas and high-risk adenomas, especially rectal adenomas.

In order to explore whether adolescent sugar intake affects the risk of CRC, the researchers investigated and analyzed 33,106 female participants in a prospective study cohort-Nurse Health Study II (NHSII) that began in 1989, and counted their participation.

The results of the dietary survey of the participants showed that 12.

After adjusting the covariate information, the logarithmic regression model was used to analyze the correlation between sugar and SSB intake and the risk of CRC, and it was found that the increase in total fructose intake during adolescence was significantly positively correlated with the risk of adenoma.

Risk ratio and 95% confidence interval of total fructose intake to colorectal polyps

In addition, the researchers also found that higher intake of SSB in adolescents was also significantly associated with higher risk of rectal adenomas, but not with serrated lesions.

The risk ratio and 95% confidence interval of the intake of sugar-sweetened beverages and colorectal polyps

Hazard ratios and 95% confidence intervals between intake of fructose and sugar-sweetened beverages and low-risk and high-risk colorectal adenomas

Adenoma is the predecessor of colorectal cancer.

Original source:

Hee-Kyung Joh, et al.