Gamma knife phase treatment of large brain metastatic tumors

Ammoren Dohm, of the Winston-Salem Wake Forest School of Medicine in North Carolina, and others who use phased SRS to treat larger brain metastatic tumors can improve the prognosis of brain metastatic tumors, the results of which are published in the July 2018 issue of Neurosurgery- Excerpted from the article chapter
.Ref: Dohm A, et al2018 Jul 1;83 (1): 114-121doi: 10.1093/neuros/nyx355WBRT often causes complications such as cognitive decline, fatigue and reduced social ability in patientsStereotactic radiosurgery (SRS), or gamma knife therapy, is precisely positioned to reduce the occurrence of complicationsAmmoren Dohm, of the Winston-Salem Wake Forest School of Medicine in North Carolina, and others who use phased SRS to treat larger brain metastatic tumors can improve the prognosis of brain metastatic tumors, the results of which are published in the July 2018 issue of Neurosurgerythe study treated patients with brain metastasis with a phased SRS treatment at intervals of 1 month, with the first dose of 10-21Gy, the median dose of 15 Gy, the second dose of 10-18Gy, and the median 14GyUse the Kaplan-Meier method to evaluate the overall lifetimeCumulative incidence analysis was made of normal brain tissue radioactive necrosis, local treatment failure (partial recurrence or volume increase of 25% of the tumor edge or center) and recurrence of distant separation (the emergence of new lesions that are not associated with the original lesions)An absolute cumulative dose-volume histogram is established for each treatment and a risk model analysis is performedresults showed that 33 patients with 39 lesions were treated with phased SRSThe total survival rates at 6 and 12 months were 65.0% and 60.0%, respectivelyThe cumulative incidence of local treatment failure in June and December was 3.2% and 13.3%, respectivelyOf the 33 cases, 4 failed treatmentFour of the 39 lesions showed radioactive necrosis of brain tissue Of the 33 patients, 2 were radiotoxicity level 4 Dosage analysis showed that the dose (Gy) received by the same brain capacity exceeded the threshold of 44.5Gy was associated with radioactive necrosis Therefore, the author thinks that staging SRS treatment of large difficult to remove brain metastasis is a safe and effective choice.