Future Science Awards announced, Zhang Tingdong / Wang Zhenyi won the Life Sciences Award!

The Future Science Prize was launched by the Hong Kong Future Science Awards Foundation Limited to reward scientists who have achieved outstanding scientific and technological achievements in Greater China, including Chinese mainland, Hong Kong, Macau and Taiwan.
Future Science Award is a folk science award co-sponsored by Chinese scientists and entrepreneurs, with three major awards, "Life Sciences" and "Material Science" and "Mathematics and Computer Science Awards", with a single prize of US$1 million, which was first awarded in 2016.
the 2020 Future Science Awards for Life Sciences are: Zhang Tingdong (First Affiliated Hospital of Harbin Medical University) and Wang Zhenyi (Ruijin Hospital, Shanghai Jiaoda University School of Medicine).
awards: Recognize their findings on the therapeutic effects of arsenic trioxide and all-trans-vitamin acid on acute early granulocytic leukemia.
cancer remains a major threat to human health.
in the process of exploring cancer treatment in humans, Zhang Tingdong and Wang Zhenyi made a decisive contribution to the cure of acute early granulocytic leukemia (APL).
APL was once one of the most dangerous and deadly leukaemias, and Zhang Tingdong and Wang Zhenyi's work led to a 90% cure rate for the APL.
years, arsenic trioxide (ATO, commonly known as arsenic) has been used in many different diseases, but its efficacy has not been reliably, repeatable and accepted.
the 1970s, zhang and his colleagues' research made it clear for the first time that the ATO could treat APL.
the 1980s, Wang Zhenyi and colleagues first demonstrated in patients that ATRA has a significant therapeutic effect on APL.
work of Zhang Tingdong and Wang Zhenyi has been internationally validated and promoted, making ATO and ATRA the standard drugs for the treatment of APL leukemia worldwide today, saving the lives of many patients.
Zhang Tingdong, was born in 1932 in Hebei Province, Harbin Medical University, the first affiliated hospital professor.
, born in 1924 in Shanghai, is a professor at Shanghai Jiaotong University.
Future Science Award Winners Previous Life Sciences Award Winners Introduced the First Winners - Lu Yuming recognizes his pioneering contribution to non-invasive prenatal fetal genetic testing based on the discovery of fetal DNA in the extraterrestal blood of pregnant women.
prenatal diagnosis of pregnant women can avoid the occurrence of fetal genetic diseases.
For example, Down syndrome, or 21 trisomy syndrome, is a common genetic disorder caused by abnormal embryonic chromosomes (an addition of chromosome 21), which results in physical retardation and intellectual disability.
can diagnose and avoid Down syndrome by prenatal check-ups for pregnant women.
, however, routine prenatal tests for Down's syndrome and similar genetic disorders require DNA analysis after amniotic puncture, a traumatic test that increases the risk of termination of pregnancy. Scientists have been working to develop non-invasive prenatal diagnostic techniques to detect genetic abnormalities in fetuses.
that although the fetus has nuclear cells that can enter the mother's blood, the number of these cells is scarce.
in his work in 1997 and 1998, Professor Lou found free FEMA in the mother's blood.
Based on these early findings, Professor Lew initiated a series of cutting-edge studies to study the characteristics of these fetal free DNA, demonstrating the feasibility and practicality of using fetal free DNA to diagnose genetic diseases, and Professor Lu's work eventually led to the use of second-generation gene sequencing to quantitatively measure fetal DNA for down syndrome testing.
non-invasion prenatal testing has been used in more than 90 countries.
china alone, more than a million pregnant women take the test each year.
this revolutionary approach provides non-invasive prenatal diagnosis to countless pregnant women around the world.
second winner, Shi Igong, recognized his significant contribution to the analysis of the structure of the key complex of the urn messenger RNA shear, revealing the active part and molecular level of the process.
the central law of molecular biology: genetic information from DNA to RNA to proteins.
all the genes of the nuclei, from yeast to human, contain exons and inclusions, the former being the DNA sequence that encodes proteins, and the latter containing no protein coding information.
the presumptogene information RNA is twelfed under the guidance of
DNA, the shear is removed by the inclusion, resulting in mature messenger RNA, which translates genetic information into the amino acid sequence of the protein it encodes.
of RNA scissors can lead to a variety of human diseases.
, however, the near-atomic resolution structure of the shear body was not clarified prior to Dr. Shi's research.
Applying the technological breakthrough of frozen electroscope in recent years, combined with the previous research on the biochemistry and structural biology of the shear body, Dr. Shi First analyzed the results of the near-atomic resolution of the electron shear, the first to reveal the active site, greatly advancing our understanding of the shear complex.
, Dr. Shi Igong analyzed the structure of three important intermediate transition complexes of the shearing process shear body, and showed the important reconstruction and structural basis of the shear function.
shigong laboratory also reported on the atomic resolution structure of human shears.
Combined with the contributions of scientists such as Dr. Reinhard Lührmann of the Institute of Biophysics and Chemistry in Marpu, Germany, and Dr. Kiyoshi Nagai of the British Molecular Biology Laboratory, the structure of Shi'igong Laboratory drives our understanding of the structure of the shearing process and provides a structural framework for the treatment of human diseases associated with shears.
third-term winners - Zhang, Yuan Longping and Li Jiayang Zhang - recognized his significant contribution to increasing rice yield through research on rice genomics and hybrid advantages and hybrid infertility molecular mechanisms.
Yuan Longping, a professor, recognized his pioneering contribution to significantly increasing rice yield and resistance through hybrid advantages.
Li Jiayang, a researcher, recognized his pioneering research on the design and cultivation of high-yielding, high-quality rice using molecular mechanisms of rice strain type and starch synthesis.
rice bears the burden of raising more than half of the population of China and the world.
the yield and quality of rice are affected by a combination of genetic and environmental complex factors, our ability to control these characters is still very limited.
, the many differences between the north and south of China put forward higher requirements for the selection and breeding of high-quality rice varieties.
, continuous improvement of the nature of rice and the realization of high yield and high quality of rice are the goals pursued by contemporary scientists.
Yuan Longping pioneered the cultivation of the first male rice infertility system, which made hybrid rice possible and was widely used in agricultural production, which greatly increased the yield of rice.
offspring produced by different parent hybridization will have better personality than parents, a phenomenon known as hybrid advantage.
rice is a self-pollination plant, naturally it is difficult to exist different parent rice hybrid offspring, hybrid advantages can not be reflected.
But the success of the breeding system of rice male infertility and hybrid rice has proved that hybrid advantages can also be applied to rice, thus laying the theoretical foundation for the effective selection of high-yielding and high-resistant rice varieties using hybrid advantages.
following Professor Yuan Longping's breakthrough work in the field of hybrid rice, Professor Zhang and Professor Li Jiayang pioneered the application of modern molecular genetics and genomics techniques to rice breeding.
Zhang inspired Professor Zhang to creatively construct a "permanent F2 group" of rice, explain the genetic basis of hybrid advantages, and for the first time discovered a gene that controls the size of rice spike grains.
results significantly reduced the randomness of hybrid breeding and greatly expanded the application of hybrid advantages in rice breeding.
and Professor Zhang's work on hybrid advantage complement each other, and Professor Li Jiayang studies the impact of rice strains on their yield, and finds that the number of rice splits and spikes are the decisive factors in yield.
He proposed to design and breed high-yielding high-quality super rice through a specific combination between strains to find the ideal strain type in the light cooperation efficiency and land utilization rate, and so on, as a guide, Professor Li Jiayang cultivated 20 new varieties of rice.
since 2016, these new varieties of rice have been planted in an area of 35 million mu.
Li Jiayang, Professor Yuan Longping and Professor Zhang Heming have achieved great achievements under the "proposition" of promoting sustainable growth in rice production.
their original work in china in the field of basic science and the national economy and people's livelihood of the great impact won the international scientific community recognized.
awarded the Future Science Award, the Life Sciences Award, to reward them for their outstanding achievements.
4th winner, Qi Feng, recognized his discovery of long-term coexistence of human beings with bacteria in human cells that respond to the inflammatory response of the pathogen endotoxin LPS and the executive protein.
most bacteria coexist peacefully with humans, helping us digest food and even fight other harmful pathogens.
the body's immune system how to distinguish between beneficial and harmful bacteria, effectively initiate immune response, is an important issue in biological research.
Over the past decade, Dr. Qi Feng's lab has provided a systematic answer: They have identified several specific cell pulp-type identification molecules (PRRs) that specifically identify invasive bacteria, revealing the molecular rationale for distinguishing between pathogenic and non-pathogenic bacteria in the host cell's inflammatory response.
most important of these is the discovery that the inflammatory protein hydrolyzed enzyme caspase-4 and -5 are intracellularly recognized endotoxin LPS (grease polysaccharides on the cell walls of Glollathyrobacteria).
bacteria invading host cells can be directly combined with inflammatory caspase 4/5 to activate cellular hormones and coke-dead patterns of cell death, promote the release of cell hormones into the bloodstream, and cause an inflammatory response against bacteria.
also found that gasdermin D in the gasdermin protein family was the agent of the substrate and cell coke death of the inflammatory caspase, as well as in the Vishva M. Dixit laboratory.
the importance of coke-based cell death in host natural immunity, the discovery of Qifeng provides a new way to explore the prevention and treatment of pathogenic infections and related diseases.
Bioworld Source: Bio Bioworld!-- Content Presentation Ends -- !-- To Determine If Login Ends.