Fundamental Research: He Jing's team reviewed the research progress of neuroblastoma liquid biopsy

Recently, He Jing's research group from the Surgery Laboratory of Pediatric Research Institute of Guangzhou Women's and Children's Medical Center published a research paper entitled: Advances in liquid biopsy in neuroblastoma in Fundamental Research, a high starting point and high-level comprehensive journal sponsored by the National Natural Science Foundation of China.

Researcher He Jing from the Institute of Pediatrics of Guangzhou Women and Children's Medical Center is the corresponding author, postdoctoral fellow Zhuo Zhenjian of Peking University Shenzhen Graduate School and graduate student Lin Lei of Guangzhou Women and Children's Medical Center affiliated to Guangzhou Medical University are the co-first authors, and Miao Lei, associate professor of Pediatrics Institute Researcher and postdoctoral fellow Li Meng are contributing authors

Even with intensive treatment of high-risk neuroblastoma (NB) patients, half of high-risk NB patients relapse

Liquid biopsies have the advantage of being less invasive than tissue biopsies

The continuous development of the current technology to detect these liquid biopsy analytes also provides increasingly reliable technical support for the application of liquid biopsy in NB tumor research

The main work of He Jing's team focuses on the molecular epidemiology and mechanism of childhood tumors.

(1) It was found that the rs174538 polymorphism of the FEN1 gene in the BER pathway can significantly reduce the risk of neurocytoma (Cancer Communications);

(2) Found that the NER pathway XPC gene has the potential to serve as a biomarker for the risk of hepatoblastoma (International Journal of Cancer);

(3) FABP4 in tumor-associated macrophages was found to inhibit the NF-κB-IL1α pathway by ubiquitinating ATPB and promote neuroblastoma progression (Clinical and Translational Medicine);

(4) Publish the latest scientific progress of targeting RAS in the treatment of neuroblastoma (Pharmacology & Therapeutics);

(5) Publish the latest scientific progress on the role and mechanism of METTL14 gene in tumors (Journal of Hematology & Oncology);

(6) Publish the latest scientific progress on the role and mechanism of m6A modification in childhood tumors (BBA - Reviews on Cancer);

(7) Published the effect of m7G modification on cancer (Trends in Cell Biology)

The He Jing team of Guangzhou Women and Children's Medical Center welcomes people with lofty ideals such as life science, statistics and medical postdoctoral fellows and graduate students to join us to create a better future

Interested parties can send an email to editor@bioon.

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