FSHW tea polyphenols-intestinal microbiota interaction: a multi-element and multi-target approach to improve metabolic syndrome

Introduction

Metabolic syndrome (MS) is defined as the association of central (abdominal) obesity with at least two factors: elevated triglycerides, reduced high-density lipoprotein (HDL) cholesterol, high blood pressure, and elevated fasting blood glucose

The human gastrointestinal tract is the habitat of trillions of microorganisms that encode more than 3 million genes

The population characteristics of the gut microbiota are closely related to diet

The effect of dietary TPs on MS through the gut microbiota

TPs improve MS in a multi-element and multi-target manner through the gut microbiota

Figure 1 The interaction between TPs and gut microbiota improves MS in a multi-element and multi-target manner

Multifunctional elements during TPs intervention

Reshape the gut microbiota

The characteristics of MS’s gut microbiota include low bacterial diversity, a significant increase in the ratio of Firmicutes to Bacteroides (F/B), and specific changes at a lower taxonomic level, such as the expansion and expansion of Proteobacteria.

Specific bacteria

The extracts in tea water are summarized as having the effect of reducing the relative abundance of the Gram-negative and sulfate-reducing Desulfovibrio, and having the effect of producing lipopolysaccharide (LPS) and inducing inflammation

Potential targets during TPs intervention

Intestinal barrier

Low-grade inflammation in MS is called "metabolic inflammation" and can promote the progression of the disease

Gut-brain axis

The intestine communicates directly or indirectly with the brain through the vagus neurotransmitter, immune system, endocrine system and microbial metabolites, forming the gut-brain axis, which affects the host's metabolism and central regulation of appetite

Conclusion and Future Perspectives

Polyphenols are natural products and have become a promising alternative therapy for metabolic disorders

Some important issues need to be simulated in future research

Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner

Hui Maa, Yaozhong Hua, Bowei Zhanga, Zeping Shaob, Eugeni Rourab,*, Shuo Wanga,*

a Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China

b Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, QLD 4072, Australia

*Corresponding authors.

E-mail address: wangshuo@nankai.

e.

Abstract

The metabolic syndrome (MS) has become one of the main problems in public health.

Reference:

MA H, HU YZ, ZHANG BW, et al.
Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner[J].
Food Science and Human Wellness, 2022, 11(1 ): 11-21.
DOI: 10.
1016/j.
fshw.
2021.
07.
002.