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Frustrated again!

 Last Update: 2021-06-08
 Source: Internet
 Author: User

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Sanofi announced on June 1 that it is stopping a key phase II/III nephropathy trial for venglustat, a new molecule that slows the progression of the disease by inhibiting abnormal accumulation of glycosphingolipids.

It is worth noting that as early as February, Sanofi reported another setback in the Phase II clinical trial of venglustat in Parkinson's disease.

Regarding the suspension, Sanofi said that the phase II/III trial of venglustat in the treatment of autosomal dominant polycystic kidney disease was cancelled because it "does not meet the invalidation criteria.

The study of venglustat in patients with autosomal dominant polycystic kidney disease is an attempt to explore new biological effects of glycosphingolipids in addition to the known role in lysosomal storage disease (LSD).

Sanofi said that the safety of venglustat is consistent with the results of previous studies of more than 500 patients treated for 4 years.

According to Dr.

So far, Sanofi has completed trials of venglustat for various LSDs related to genetic abnormalities.

Reference source: Sanofi Halts Kidney Disease Program Studying Venglustat Drug

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