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Frontiers Chinese scholars: Are you afraid of dementia?

 Last Update: 2022-01-23
 Source: Internet
 Author: User

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As the global population ages rapidly, cognitive impairments, such as dementia, pose serious implications for public health and the social and economic development of modern societies
.

A large body of evidence suggests that both genetic and life>

More specifically, existing studies have shown that

A total of 3017 participants (mean age 77.
0 years, SD = 9.
0; 49.
3% women) were recruited from 23 provinces in China in 2008, and re-interviews were conducted in 2014
.

Cognitive function was assessed using the Mini Mental Status Examination (MMSE)

RESULTS: During follow-up, moderate and significant cognitive decline was detected in 685 (22.
8%) and 723 (23.
7%) participants, respectively
.

Independent of potential confounders, there was a clear association between APOE ε4 and faster cognitive decline (OR=1.

Association between leisure activity index and cognitive decline in the presence of the APOE ε4 allele

A significant interaction between APOE ε4 and leisure activities was further found, with a P value of 0.
018
.

At the same time, an interaction of leisure activity subtypes was also observed: participants who frequently engaged in productive activities were more likely to have a reduced risk of APOE ε4-related cognitive decline

Taken together, this study suggests that participation in leisure activities can delay cognitive decline, which is significantly opposite to the impairment of cognitive health caused by APOEε4 carrying

references:

Leisure Activities, APOE ε4, and Cognitive Decline: A Longitudinal Cohort Study.

Leisure Activities, APOE ε4, and Cognitive Decline: A Longitudinal Cohort Study.
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