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Front.aging neurosci-Alzheimer's disease mouse model hippocampal CA1 N-methyl-D-aspartate receptor functional defect and synaptic plasticity

 Last Update: 2021-12-26
 Source: Internet
 Author: User

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Alzheimer's disease (AD) is a progressive neurological disease characterized by impaired learning and memory functions, resulting in cognitive dysfunction
.
The hippocampus volume of AD patients is reduced, especially the hippocampal CA1 area is one of the most severely damaged areas, which can be used as an auxiliary examination area to improve the accuracy of AD diagnosis

Research result

The cognitive impairment of APPS1/PS1 mice at 6/8 months of age

References Le Xu, Yiying Zhou, Linbo Hu, Hongde Jiang, Yibei Dong, Haowei Shen, Zhongze Lou, Siyu Yang, Yunxin Ji, Liemin Ruan and Xiaoqin Zhang, Deficits in N-Methyl-D-Aspartate Receptor Function and Synaptic Plasticity in Hippocampal CA1 in APP/PS1 Mouse Model of Alzheimer's Disease, Front.
Aging Neurosci.

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