Front Oncol: The prognostic role of the number of resected lymph nodes in stage II small bowel adenocarcinoma (SBA) based on the SEER database

Treatment strategies for small bowel adenocarcinoma (SBA) are controversial due to the lack of large-scale clinical trials, especially in stage II patients
.

According to the National Comprehensive Cancer Network (NCCN) guidelines, insufficient examination of lymph nodes (LNs) (<5 duodenum and <8 primary sites of jejunum/ileum) is one of the high-risk factors for stage II patients, and adjuvant chemotherapy is recommended

Treatment strategies for small bowel adenocarcinoma (SBA) are controversial due to the lack of large-scale clinical trials, especially in stage II patients

However, since 2004, surgical approaches and chemotherapy strategies for SBA patients have changed considerably

A total of 935 patients with stage II SBA met the inclusion criteria, including 413 (44.
2%) in duodenum and 522 (55.
8%) in jejunum and ileum
.

The two groups of patients were similar in gender, age, grade, ethnicity and region

A total of 935 patients with stage II SBA met the inclusion criteria, including 413 (44.

The Optimal Number of Lymph Nodes Resection Study found that in patients with duodenal cancer who had at least 5 LNs removed (HR: 0.
39, 95% CI, 0.
26 to 0.
58, Pearson's chi-square: 20.
69, p < 0.
0001) and jejunum/ileum The difference in survival was greatest among cancer patients who had at least 12 LNs removed (HR: 0.
71, 95% CI, 0.
52 to 0.
98, Pearson's chi-square: 4.
253, p = 0.
0392)
.

The Optimal Number of Lymph Nodes Resection Study found that in patients with duodenal cancer who had at least 5 LNs removed (HR: 0.
39, 95% CI, 0.
26 to 0.
58, Pearson's chi-square: 20.
69, p < 0.
0001) and jejunum/ileum The difference in survival was greatest among cancer patients who had at least 12 LNs removed (HR: 0.
71, 95% CI, 0.
52 to 0.
98, Pearson's chi-square: 4.
253, p = 0.
0392)
.

The Optimal Number of Lymph Nodes Resection Study found that in patients with duodenal cancer who had at least 5 LNs removed (HR: 0.

Multivariate Cox analysis showed that we could see that older age (≧45 years), T4 and higher histological grade were negative prognostic factors
.

Patients with jejunal/ileal tumors had better CSS than duodenal tumors (HR: 0.

Multivariate Cox analysis showed that we could see that older age (≧45 years), T4 and higher histological grade were negative prognostic factors

Taken together, the study demonstrated that the number of resected LNs was an important prognostic factor for survival in patients with stage II SBA
.

The number of LNs examined <5 remains a high risk factor for duodenal tumors, but the breakdown point for jejunal/ileal tumors should rise from 8 to 12

Taken together, the study demonstrated that the number of resected LNs was an important prognostic factor for survival in patients with stage II SBA

Original source:

Original source:

Liu Z, Liu K, Gao J, Jing C, Ma Y, Zheng S and Shan J (2022) Prognostic Value of Lymph Node Evaluation in Stage II Small Bowel Adenocarcinoma: An Updated Analysis of Surveillance, Epidemiology, and End Results Database.

Liu Z, Liu K, Gao J, Jing C, Ma Y, Zheng S and Shan J (2022) Prognostic Value of Lymph Node Evaluation in Stage II Small Bowel Adenocarcinoma: An Updated Analysis of Surveillance, Epidemiology, and End Results Database.
Front .
Oncol.
12:865745.
doi: 10.
3389/fonc.
2022.
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