Front Oncol: The efficacy of initial laparoscopic surgery (PLA) and open surgery (OA) in the treatment of T1b/T2 stage gallbladder cancer (GBC) patients

Gallbladder carcinoma (GBC) is the most common malignant tumor of the biliary tract, with high mortality and poor prognosis
.

Due to the lack of optimal treatment, GBC is considered a highly fatal disease, with a 5-year survival rate of less than 5%

Gallbladder carcinoma (GBC) is the most common malignant tumor of the biliary tract, with high mortality and poor prognosis

Research Screening 2011 Nian 1 Yue Zhi 2018 Nian 8 month period diagnosis T1b / T2 GBC surgical patients
.

Assess overall survival (OS) , disease-free survival (DFS) and safety

Research Screening 2011 Nian 1 Yue Zhi 2018 Nian 8 month period diagnosis T1b / T2 GBC surgical patients

A total of 114 patients were included in the study, of which 61 were treated with OA and 53 were treated with PLA

Number of PLA and OA treatments at different time points

Number of PLA and OA treatments at different time points

Compared with PLA and OA treatment, OS (HR=1.
572; 95%CI: 0.
866 2.
855; p = 0.
13) and DFS (HR=1.
225; 95% CI, 0.
677 2.
218; p = 0.
49) were not statistically different between the two groups
.

Compared with PLA and OA treatment, OS (HR=1.
572; 95%CI: 0.
866 2.
855; p = 0.
13) and DFS (HR=1.
225; 95% CI, 0.
677 2.
218; p = 0.
49) were not statistically different between the two groups
.

Compared with PLA and OA treatment, OS (HR=1.

            OS treated in both groups

OS treated in both groups

              DFS treated in both groups

              DFS treated in both groups

In addition, there were fewer intraoperative drainages after PLA, but there was no significant difference between the two groups (PLA 1.
3 vs.
OA 1.
4, p = 0.
253)
.

PLA does not significantly increase the intraoperative blood loss of GBC patients (PLA 257.

In addition, there were fewer intraoperative drainages after PLA, but there was no significant difference between the two groups (PLA 1.

            Comparison of secondary prognostic indicators of treatment between the two groups

Comparison of secondary prognostic indicators of treatment between the two groups

Multivariate analysis found that LNs positive (p = 0.
032) and tumor differentiation (p = 0.
048) were independent risk factors for OS after PLA .
Multivariate analysis did not find independent risk factors for DFS after PLA .
Patients with good or poor OS who were treated with PLA had similar recurrence rates (p = 0.
402) .
In addition, positive LNs (p = 0.
005) was considered an independent risk factor for OS after OA .
In addition, age (p = 0.
013) , gallbladder stones (p = 0.
008) , tumor size (p = 0.
028) and positive LNs (p = 0.
044) are potential risk factors for DFS after OA .

Multivariate analysis found that LNs positive (p = 0.

032) and tumor differentiation (p = 0.
048) were independent risk factors for OS after PLA .
Multivariate analysis did not find independent risk factors for DFS after PLA .
Patients with good or poor OS who were treated with PLA had similar recurrence rates (p = 0.
402) .

In summary, studies have shown that PLA for T1b/T2 stage GBC is comparable to OA in terms of perioperative and long-term outcomes

Original source:

Cao J, Wang Y, Zhang B, Hu J, Topatana W, Li S, Juengpanich S, Lu Z, Cai X and Chen M (2021) Comparison of Outcomes After Primary Laparoscopic Versus Open Approach for T1b/T2 Gallbladder Cancer.

Front.
Oncol.
11:758319.
doi: 10.
3389/fonc.
2021.
758319

Cao J, Wang Y, Zhang B, Hu J, Topatana W, Li S, Juengpanich S, Lu Z, Cai X and Chen M (2021) Comparison of Outcomes After Primary Laparoscopic Versus Open Approach for T1b/T2 Gallbladder Cancer.
Front.
Oncol.
11:758319.
doi: 10.
3389/fonc.
2021.
758319 leave a message here